| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendicular and extra-appendicular origin |
| Creator | Delhorme et al. |
| Author | J.-B. Delhorme |
| Author | F. Severac |
| Author | G. Averous |
| Author | O. Glehen |
| Author | G. Passot |
| Author | N. Bakrin |
| Author | F. Marchal |
| Author | M. Pocard |
| Author | R. Lo Dico |
| Author | C. Eveno |
| Author | S. Carrere |
| Author | O. Sgarbura |
| Author | F. Quenet |
| Author | G. Ferron |
| Author | D. Goéré |
| Author | C. Brigand |
| Abstract | BACKGROUND: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database. Patients with EA-PMP had pathologically confirmed non-neoplastic appendices and were matched in a 1 : 4 ratio with patients treated for appendicular PMP (A-PMP), based on a propensity score. RESULTS: Some 726 patients were identified, of which 61 (EA-PMP group) were matched with 244 patients (A-PMP group). The origins of primary tumours in the EA-PMP group included the ovary (45 patients), colon (4), urachus (4), small bowel (1), pancreas (1) and unknown (6). The median peritoneal carcinomatosis index was comparable in EA-PMP and A-PMP groups (15·5 versus 18 respectively; P?=?0·315). In-hospital mortality (3 versus 2·9?per cent; P?=?1·000) and major morbidity 26 versus 25·0?per cent; P?=?0·869) were also similar between the two groups. Median follow-up was 66·9?months. The 5-year overall survival rate was 87·8 (95?per cent c.i. 83·2 to 92·5) per cent in the A-PMP group and 87 (77 to 96) per cent in the EA-PMP group. The 5-year disease-free survival rate was 66·0 (58·7 to 73·4) per cent and 70 (53 to 83) per cent respectively. CONCLUSION: Overall and disease-free survival following treatment with CCRS and HIPEC is similar in patients with pseudomyxoma peritonei of appendicular or extra-appendicular origin. |
| Publication | The British Journal of Surgery |
| Volume | 105 |
| Issue | 6 |
| Pages | 668-676 |
| Date | 05 2018 |
| Journal Abbr | Br J Surg |
| Language | eng |
| DOI | 10.1002/bjs.10716 |
| ISSN | 1365-2168 |
| Library Catalog | PubMed |
| Extra | IMPACT: 5.433 PMID: 29412465 |
| Tags | Appendiceal Neoplasms, clinic, Cytoreduction Surgical Procedures, Disease-Free Survival, Female, Humans, Hyperthermia, Induced, inca, Male, Middle Aged, Peritoneal Neoplasms, Prognosis, Retrospective Studies, Survival Analysis |
| Date Added | 2019/01/04 - 17:57:50 |
| Date Modified | 2021/03/05 - 10:44:02 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
