| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | Triplet chemotherapy in combination with anti-EGFR agents for the treatment of metastatic colorectal cancer: Current evidence, advances, and future perspectives |
| Creator | Folprecht et al. |
| Author | Gunnar Folprecht |
| Author | Erika Martinelli |
| Author | Thibault Mazard |
| Author | Dominik P. Modest |
| Author | Akihito Tsuji |
| Author | Regina Esser |
| Author | Chiara Cremolini |
| Author | Alfredo Falcone |
| Abstract | Doublet or triplet chemotherapy regimens in combination with anti-epidermal growth factor receptor (anti-EGFR) monoclonal antibodies (mAb), such as cetuximab or panitumumab, or the anti-vascular endothelial growth factor mAb bevacizumab, are the current recommended standard of care therapies for unresectable metastatic colorectal cancer (mCRC). While the recommended dosing schedule for the triplet chemotherapy regimen with 5-fluorouracil, oxaliplatin and irinotecan (FOLFOXIRI) in combination with bevacizumab is well established, the optimal dosing of FOLFOXIRI in combination with anti-EGFR agents is unknown. Several randomized, phase 3 clinical trials of patients with mCRC have demonstrated improved survival and response rates with FOLFOXIRI, alone or when combined with bevacizumab, compared with doublet chemotherapy regimens. Trials of anti-EGFR agents in combination with FOLFOXIRI have also shown promising results. In this review, we summarize the emerging evidence regarding the safety and efficacy of anti-EGFR agents in combination with triplet chemotherapy regimens and discuss the potential for this combination as a future treatment option for patients with RAS-wild-type mCRC. |
| Publication | Cancer Treatment Reviews |
| Volume | 102 |
| Pages | 102301 |
| Date | 2022-01 |
| Journal Abbr | Cancer Treat Rev |
| Language | eng |
| DOI | 10.1016/j.ctrv.2021.102301 |
| ISSN | 1532-1967 |
| Short Title | Triplet chemotherapy in combination with anti-EGFR agents for the treatment of metastatic colorectal cancer |
| Library Catalog | PubMed |
| Extra | PMID: 34839118 |
| Tags | Anti-EGFR, Antineoplastic Combined Chemotherapy Protocols, Camptothecin, Cetuximab, Chemotherapy, Clinical Trials, Phase III as Topic, Colorectal Neoplasms, ErbB Receptors, Fluorouracil, FOLFOXIRI, Humans, Leucovorin, mCRC, Neoplasm Metastasis, Organoplatinum Compounds, Protein Kinase Inhibitors, Randomized Controlled Trials as Topic |
| Date Added | 2022/08/30 - 16:16:38 |
| Date Modified | 2024/10/10 - 16:52:14 |
| Notes and Attachments | PubMed entry (Attachment) |
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