| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | The performance of PI-RADSv2 and quantitative apparent diffusion coefficient for predicting confirmatory prostate biopsy findings in patients considered for active surveillance of prostate cancer |
| Creator | Nougaret et al. |
| Author | Stephanie Nougaret |
| Author | Nicola Robertson |
| Author | Jennifer Golia Pernicka |
| Author | Nicolas Molinari |
| Author | Andreas M. Hötker |
| Author | Behfar Ehdaie |
| Author | Evis Sala |
| Author | Hedvig Hricak |
| Author | Hebert Alberto Vargas |
| Abstract | PURPOSE: To assess the performance of the updated Prostate Imaging Reporting and Data System (PI-RADSv2) and the apparent diffusion coefficient (ADC) for predicting confirmatory biopsy results in patients considered for active surveillance of prostate cancer (PCA). METHODS: IRB-approved, retrospective study of 371 consecutive men with clinically low-risk PCA (initial biopsy Gleason score ?6, prostate-specific antigen <10 ng/ml, clinical stage ?T2a) who underwent 3T-prostate MRI before confirmatory biopsy. Two independent radiologists recorded the PI-RADSv2 scores and measured the corresponding ADC values in each patient. A composite score was generated to assess the performance of combining PI-RADSv2 + ADC. RESULTS: PCA was upgraded on confirmatory biopsy in 107/371 (29%) patients. Inter-reader agreement was substantial (PI-RADSv2: k = 0.73; 95% CI [0.66-0.80]; ADC: r = 0.74; 95% CI [0.69-0.79]). Accuracies, sensitivities, specificities, positive predicted value and negative predicted value of PI-RADSv2 were 85, 89, 83, 68, 95 and 78, 82, 76, 58, 91% for ADC. PI-RADSv2 accuracy was significantly higher than that of ADC for predicting biopsy upgrade (p = 0.014). The combined PI-RADSv2 + ADC composite score did not perform better than PI-RADSv2 alone. Obviating biopsy in patients with PI-RADSv2 score ?3 would have missed Gleason Score upgrade in 12/232 (5%) of patients. CONCLUSION: PI-RADSv2 was superior to ADC measurements for predicting PCA upgrading on confirmatory biopsy. |
| Publication | Abdominal Radiology (New York) |
| Volume | 42 |
| Issue | 7 |
| Pages | 1968-1974 |
| Date | 07 2017 |
| Journal Abbr | Abdom Radiol (NY) |
| Language | eng |
| DOI | 10.1007/s00261-017-1086-7 |
| ISSN | 2366-0058 |
| Library Catalog | PubMed |
| Extra | PMID: 28258355 PMCID: PMC5537601 |
| Tags | Adult, Aged, Aged, 80 and over, Biopsy, clinic, Confirmatory, Contrast Media, Diffusion Magnetic Resonance Imaging, Humans, Male, Middle Aged, Neoplasm Grading, PI-RADSv2, Predictive Value of Tests, Prostate, Prostatic Neoplasms, Retrospective Studies, Sensitivity and Specificity |
| Date Added | 2018/11/13 - 17:35:23 |
| Date Modified | 2019/05/21 - 13:44:42 |
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