| Added by | llasorsa |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | A New Paradigm of the Origins of Circulating DNA in Patients with Cancer |
| Creator | Thierry and Pisareva |
| Author | Alain R. Thierry |
| Author | Ekaterina Pisareva |
| Abstract | By shedding light on the cellular origins of circulating DNA (cirDNA), this research provides important insights into the mechanisms of cirDNA production in cancer. Contrary to expectations, the increased cirDNA in patients with cancer was not derived predominantly from neoplastic cells or surrounding nonneoplastic epithelial cells; rather, the excess cirDNA originated primarily from leukocytes, implying a systemic impact of cancer on cell turnover or DNA clearance. See related article by Mattox et al., p. 2166 (1). |
| Publication | Cancer Discovery |
| Volume | 13 |
| Issue | 10 |
| Pages | 2122-2124 |
| Date | 2023-10-05 |
| Journal Abbr | Cancer Discov |
| Language | eng |
| DOI | 10.1158/2159-8290.CD-23-0824 |
| ISSN | 2159-8290 |
| Library Catalog | PubMed |
| Extra | PMID: 37794839 |
| Tags | Cell-Free Nucleic Acids, Colorectal Neoplasms, DNA, Female, Humans, Lung, Ovarian Neoplasms |
| Date Added | 2024/10/07 - 16:44:53 |
| Date Modified | 2024/10/07 - 16:44:53 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
