| Added by | amaraver |
|---|---|
| Group name | EquipeAM |
| Item Type | Journal Article |
| Title | Odours of cancerous mouse congeners: detection and attractiveness |
| Creator | Gouzerh et al. |
| Author | Flora Gouzerh |
| Author | Bruno Buatois |
| Author | Maxime R. Hervé |
| Author | Maicol Mancini |
| Author | Antonio Maraver |
| Author | Laurent Dormont |
| Author | Frédéric Thomas |
| Author | Guila Ganem |
| Abstract | Chemical communication plays a major role in social interactions. Cancer, by inducing changes in body odours, may alter interactions between individuals. In the framework of research targeting non-invasive methods to detect early stages of cancer development, this study asked whether untrained mice could detect odour changes in cancerous congeners. If yes, were they able to detect cancer at an early developmental stage? Did it influence female preference? Did variations in volatile organic components of the odour source paralleled mice behavioural responses? We used transgenic mice strains developing or not lung cancer upon antibiotic ingestion. We sampled soiled bedding of cancerous mice (CC) and not cancerous mice (NC), at three experimental conditions: before (T0), early stage (T2) and late stage (T12) of cancer development. Habituation/generalisation and two-way preference tests were performed where soiled beddings of CC and NC mice were presented to wild-derived mice. The composition and relative concentration of volatile organic components (VOC) in the two stimuli types were analysed. Females did not show directional preference at any of the experimental conditions, suggesting that cancer did not influence their choice behaviour. Males did not discriminate between CC and NC stimuli at T0 but did so at T2 and T12, indicating that wild-derived mice could detect cancer at an early stage of development. Finally, although the VOC bouquet differed between CC and NC it did not seem to parallel the observed behavioural response suggesting that other types of odorant components might be involved in behavioural discrimination between CC and NC mice. |
| Publication | Biology Open |
| Volume | 11 |
| Issue | 4 |
| Pages | bio059208 |
| Date | 2022-04-15 |
| Journal Abbr | Biol Open |
| Language | eng |
| DOI | 10.1242/bio.059208 |
| ISSN | 2046-6390 |
| Short Title | Odours of cancerous mouse congeners |
| Library Catalog | PubMed |
| Extra | PMID: 35403195 PMCID: PMC9065363 |
| Tags | Animals, Body odours, EGFR oncogenic mutation, Female, Female preference, Male, Mice, Mus musculus domesticus, Neoplasms, Odorants, Odour discrimination, original, Volatile Organic Compounds |
| Date Added | 2022/08/31 - 14:01:42 |
| Date Modified | 2022/08/31 - 14:05:41 |
| Notes and Attachments | Full Text (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
