| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Complete pathologic response after two-stage cytoreductive surgery with HIPEC for bulky pseudomyxoma peritonei: proof of concept |
| Creator | Sgarbura et al. |
| Author | Olivia Sgarbura |
| Author | Mohammed Al Hosni |
| Author | Andrea Petruzziello |
| Author | Rodrigo Figueroa |
| Author | Lakhdar Khellaf |
| Author | Marie-Hélène Pissas |
| Author | Sébastien Carrère |
| Author | Stephanie Nougaret |
| Author | Frédéric Bibeau |
| Author | François Quénet |
| Abstract | Introduction: Pseudomyxoma peritonei (PMP) is a rare disease characterized by the progressive accumulation of mucinous ascites and peritoneal implants. The optimal treatment for PMP includes the association of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC). For patients with a large burdensome disease, the completeness of cytoreduction sometimes requires maximal effort surgery. The aim of this article is to provide proof of concept for two stage cytoreductive surgery (CRS) in this category of patients.Methods and materials: A two stage CRS and HIPEC with oxaliplatin was proposed for patients with bulky PMP including important involvement of the serosal surfaces of the bowel or colon who had an impaired nutritional status. The residual disease at the end of the first stage was less than 5?mm of thickness on several implants. Clinical, surgical and histopathological variables were analyzed.Results: All eight patients completed the two-stage strategy. Mortality was nil. One Clavien Dindo grade 3 event occurred in each stage. After a median follow up of 29.5?months, all patients were alive and free of recurrence. All of the patients had histopathological complete response on the specimens obtained from the residual sites during the second stage surgery.Conclusions: Two-stage surgical strategy is feasible for bulky PMP patients and it is associated with little high-grade morbidity and enhanced visceral sparing. |
| Publication | International Journal of Hyperthermia: The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group |
| Volume | 37 |
| Issue | 1 |
| Pages | 585-591 |
| Date | 2020 |
| Journal Abbr | Int J Hyperthermia |
| Language | eng |
| DOI | 10.1080/02656736.2020.1772511 |
| ISSN | 1464-5157 |
| Short Title | Complete pathologic response after two-stage cytoreductive surgery with HIPEC for bulky pseudomyxoma peritonei |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 32484014 |
| Tags | clinic, hyperthermic intraperitoneal chemotherapy, last, oxaliplatin, Pseudomyxoma peritonei, two-stage surgery |
| Date Added | 2020/06/05 - 11:51:04 |
| Date Modified | 2020/06/05 - 11:54:14 |
| Notes and Attachments | Full Text (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
