| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Association between FGFR1 copy numbers, MAP3K1 mutations, and survival in axillary node-positive, hormone receptor-positive, and HER2-negative early breast cancer in the PACS04 and METABRIC studies |
| Creator | Carene et al. |
| Author | Dimitri Carene |
| Author | Alicia Tran-Dien |
| Author | Jérôme Lemonnier |
| Author | Florence Dalenc |
| Author | Christelle Levy |
| Author | Jean-Yves Pierga |
| Author | William Jacot |
| Author | Jean-Luc Canon |
| Author | Catherine Richon |
| Author | Ludovic Lacroix |
| Author | Christophe Caux |
| Author | Fabrice André |
| Author | Stefan Michiels |
| Abstract | PURPOSE: Hormone receptor-positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) early breast cancer (BC) is the most prevalent BC subtype with substantial biological heterogeneity. Although clinicopathological (CP) characteristics have a clear prognostic value, additional biomarkers could refine survival prediction and guide treatment decision. METHODS: Copy number aberrations and somatic driver mutations were obtained with OncoScan CGH array and sequencing of 36 genes on HR+/HER2- node-positive early BC patients treated with chemotherapy from the PACS04 trial. We built a two-gene genomic score (GS) associated with distant disease-free survival (DDFS), whose prognostic value was assessed on the external METABRIC data (n?=?1413) using overall survival (OS) and breast cancer-specific survival (BCSS). RESULTS: In the PACS04 trial (n?=?327), the median follow-up for DDFS (65 events) was 9.6 years. FGFR1 amplifications ([Formula: see text]?=?2.44, 95% CI [1.25; 4.76], p?=?0.009) and MAP3K1 mutations ([Formula: see text]?=?0.10, [0.01; 0.78], p?=?0.03) were associated with DDFS beyond CP characteristics. A prognostic GS combining FGFR1 amplifications and MAP3K1 mutations added more information to CP model ([Formula: see text]?=?12.97, [Formula: see text]? |
| Publication | Breast Cancer Research and Treatment |
| Date | Oct 16, 2019 |
| Journal Abbr | Breast Cancer Res. Treat. |
| Language | eng |
| DOI | 10.1007/s10549-019-05462-y |
| ISSN | 1573-7217 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 31620934 |
| Tags | Biomarkers, Breast cancer (BC), clinic, Copy number aberrations (CNA), Cox regression |
| Date Added | 2020/01/21 - 10:51:54 |
| Date Modified | 2020/01/21 - 11:01:58 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
