| Added by | mollevi |
|---|---|
| Last modified by | André Pèlegrin |
| Group name | EquipeAP |
| Item Type | Journal Article |
| Title | [The breakthrough of personalized medicine, new hopes and new challenges] |
| Creator | Flippot et al. |
| Author | R. Flippot |
| Author | C. Massard |
| Author | E. Auclin |
| Author | D. Azria |
| Author | H. Bourien |
| Author | P. Rochigneux |
| Author | A. Schernberg |
| Author | L. Verlingue |
| Author | L. Zafrani |
| Author | S. Vignot |
| Abstract | The development of personalized medicine in oncology is based on biomarkers that help select populations for more efficient and less toxic therapies. The onset of molecular biology led to new paradigms in drug development, with efficacy data reported in early clinical trials and accelerated approvals. Multiple clinical trials, including SHIVA, SAFIR-01 and MOSCATO-01, have been developed to evaluate the interest of treatment decision-making based on tumor molecular profiling, with the ambition to replace historical clinical and pathological classifications. Targeted molecular therapies have also drastically enhanced the prognosis of patients in several cancer subtypes, with increased use in the context of advanced palliative care. Breaking through those boundaries might lead to a true precision medicine in oncology, which implementation in clinical routine is now expected by patients and physicians. |
| Publication | Bull Cancer |
| Date | Aug 11 2017 |
| Journal Abbr | Bulletin du cancer |
| DOI | 10.1016/j.bulcan.2017.07.003 |
| ISSN | 1769-6917 (Electronic) 0007-4551 (Linking) |
| Tags | Antineoplastic Agents, Biomarker, Biomarkers, Tumor, Biomarqueur, Clinical Trials as Topic, Decision Making, didactique, Drug Discovery, Humans, Médecine personnalisée, Medical Oncology, Molecular targeted therapies, Neoplasms, nonvisible, Personalized medicine, Precision Medicine, review, Thérapies moléculaires ciblées |
| Date Added | 2018/07/20 - 10:01:50 |
| Date Modified | 2019/12/11 - 18:28:09 |
| Notes and Attachments | (Note) (Note) 28807365 (Attachment) |
Institut de Recherche en Cancérologie de
