| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Impact of adjuvant hormonotherapy on radiation-induced breast fibrosis according to the individual radiosensitivity: results of a multicenter prospective French trial |
| Creator | Bourgier et al. |
| Author | Céline Bourgier |
| Author | Florence Castan |
| Author | Olivier Riou |
| Author | Tan-Dat Nguyen |
| Author | Karine Peignaux |
| Author | Claire Lemanski |
| Author | Jean-Léon Lagrange |
| Author | Youlia Kirova |
| Author | Eric Lartigau |
| Author | Yazid Belkacemi |
| Author | Sofia Rivera |
| Author | Georges Noël |
| Author | Sébastien Clippe |
| Author | Françoise Mornex |
| Author | Christophe Hennequin |
| Author | Sophie Gourgou |
| Author | Muriel Brengues |
| Author | Pascal Fenoglietto |
| Author | Esat Mahmut Ozsahin |
| Author | David Azria |
| Abstract | Background: To evaluate risk of severe breast fibrosis occurrence in patients treated by breast-conserving surgery, adjuvant radiotherapy and hormonotherapy (HT) according to individual radiosensitivity (RILA assay). Results: HT- and RILAhigh were the two independent factors associated with improved breast-fibrosis free survival (BFFS). BFFS rate at 36 months was lower in patients with RILAlow and HT+ than in patients with RILAhigh and HT- (75.8% and 100%, respectively; p = 0.004, hazard ratio 5.84 [95% confidence interval (CI) 1.8-19.1]). Conversely, BFFS at 36 months was comparable in patients with RILAhigh and HT+ and in patients with RILAlow and HT- (89.8% and 93.5%, respectively; p = 0.39, hazard ratio 1.7 [95% CI 0.51-5.65]), showing that these two parameters influenced independently the occurrence of severe breast fibrosis. BFFS rate was not affected by the HT type (tamoxifen or aromatase inhibitor) and timing (concomitant or sequential with radiotherapy). Conclusions: HT and RILA score independently influenced BFFS rate at 36 months. Patients with RILAhigh and HT- presented an excellent BFFS at 36 months (100%). Materials and methods: Breast Fibrosis-Free Survival (BFFS) rate was assessed relative to RILA categories and to adjuvant HT use (HT+ and HT-, respectively) in a prospective multicentre study (NCT00893035) which enrolled 502 breast cancer patients (456 evaluable patients). Breast fibrosis was recorded according to CTCAE v3.0 grading scale; RILA score was defined according to two categories (<12%: RILAlow; ?12%: RILAhigh). |
| Publication | Oncotarget |
| Volume | 9 |
| Issue | 21 |
| Pages | 15757-15765 |
| Date | Mar 20, 2018 |
| Journal Abbr | Oncotarget |
| Language | eng |
| DOI | 10.18632/oncotarget.24606 |
| ISSN | 1949-2553 |
| Short Title | Impact of adjuvant hormonotherapy on radiation-induced breast fibrosis according to the individual radiosensitivity |
| Library Catalog | PubMed |
| Extra | PMID: 29644007 PMCID: PMC5884662 |
| Tags | breast cancer, clinic, individual radiosensitivity, late effects |
| Date Added | 2019/05/28 - 21:58:39 |
| Date Modified | 2019/05/28 - 21:59:02 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
