| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Is post-mastectomy radiation therapy contributive in pN0-1mi breast cancer patients? Results of a French multi-centric cohort |
| Creator | Forissier et al. |
| Author | Violaine Forissier |
| Author | Agnès Tallet |
| Author | Monique Cohen |
| Author | Jean-Marc Classe |
| Author | Fabien Reyal |
| Author | Nicolas Chopin |
| Author | Chafika Mazouni |
| Author | Pierre Gimbergues |
| Author | Emile Daraï |
| Author | Pierre Emmanuel Colombo |
| Author | Pierre Azuar |
| Author | Eric Lambaudie |
| Author | Gilles Houvenaeghel |
| Abstract | AIM: To assess the value of post-mastectomy radiation therapy (PMRT) to breast cancer (BC) patients with no or minimal lymph node (LN) involvement. MATERIALS AND METHODS: We retrospectively analysed a French multi-centric cohort of 4283 patients treated by mastectomy and axillary dissection, with or without PMRT, between 1980 and 2013. Practices were analysed for three treatment periods (1980-1999, 2000-2005 and 2006-2013). The impact of PMRT on loco-regional recurrence (LRR), disease-free survival (DFS), BC-specific survival and overall survival was assessed in pN0-1mi patients using multivariate analyses (logistic regression and Cox model). It was subsequently assessed based on the number of clinicopathological recurrence-risk factors, generating a prognostic index (French-PMRT index), to isolate a pN0-1mi patients subgroup that might derive a benefit from PMRT. We tested the accuracy of the Cambridge-PMRT (c-PMRT) index to discriminate between patients with significantly different outcomes and the value of PMRT in each c-PMRT prognostic group. RESULTS: More than half of the pN0-1mi patients of our cohort underwent PMRT, which almost significantly improved LRR-free survival and DFS. Matching pN0-1mi patients based on the number of clinicopathologic recurrence-risk factors identified a higher risk subpopulation (?3 recurrence-risk factors), but PMRT did not improve patient outcomes. Although the c-PMRT index had the potential to predict patient outcomes, its use did not help in making the decision of whether or not to use PMRT. CONCLUSION: We failed to isolate a subgroup of early BC patients without LN involvement suitable for PMRT, despite studying a large cohort. |
| Publication | European Journal of Cancer (Oxford, England: 1990) |
| Volume | 87 |
| Pages | 47-57 |
| Date | 12 2017 |
| Journal Abbr | Eur. J. Cancer |
| Language | eng |
| DOI | 10.1016/j.ejca.2017.10.004 |
| ISSN | 1879-0852 |
| Short Title | Is post-mastectomy radiation therapy contributive in pN0-1mi breast cancer patients? |
| Library Catalog | PubMed |
| Extra | PMID: 29107861 |
| Tags | Adult, Aged, Breast Neoplasms, Chi-Square Distribution, clinic, Disease-Free Survival, Female, France, Humans, Isolated tumor cells, Kaplan-Meier Estimate, Logistic Models, Mastectomy, Micrometastasis, Middle Aged, Multivariate Analysis, Negative lymph node, Neoplasm Recurrence, Local, Neoplasm Staging, Patient Selection, PMRT, Proportional Hazards Models, Radiotherapy, Adjuvant, Retrospective Studies, Risk Assessment, Risk Factors, stan, Time Factors, Treatment Outcome |
| Date Added | 2018/11/14 - 15:24:24 |
| Date Modified | 2019/05/14 - 20:12:56 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
