| Added by | lklinares |
|---|---|
| Group name | EquipeLL |
| Item Type | Journal Article |
| Title | Even Cancer Cells Watch Their Cholesterol! |
| Creator | Riscal et al. |
| Author | Romain Riscal |
| Author | Nicolas Skuli |
| Author | M. Celeste Simon |
| Abstract | Deregulated cell proliferation is an established feature of cancer, and altered tumor metabolism has witnessed renewed interest over the past decade, including the study of how cancer cells rewire metabolic pathways to renew energy sources and "building blocks" that sustain cell division. Microenvironmental oxygen, glucose, and glutamine are regarded as principal nutrients fueling tumor growth. However, hostile tumor microenvironments render O2/nutrient supplies chronically insufficient for increased proliferation rates, forcing cancer cells to develop strategies for opportunistic modes of nutrient acquisition. Recent work shows that cancer cells overcome this nutrient scarcity by scavenging other substrates, such as proteins and lipids, or utilizing adaptive metabolic pathways. As such, reprogramming lipid metabolism plays important roles in providing energy, macromolecules for membrane synthesis, and lipid-mediated signaling during cancer progression. In this review, we highlight more recently appreciated roles for lipids, particularly cholesterol and its derivatives, in cancer cell metabolism within intrinsically harsh tumor microenvironments. |
| Publication | Molecular Cell |
| Volume | 76 |
| Issue | 2 |
| Pages | 220-231 |
| Date | 2019-10-17 |
| Journal Abbr | Mol Cell |
| Language | eng |
| DOI | 10.1016/j.molcel.2019.09.008 |
| ISSN | 1097-4164 |
| Library Catalog | PubMed |
| Extra | PMID: 31586545 PMCID: PMC7225778 |
| Tags | Animals, bile acids, cancer, Cell Proliferation, Cholesterol, Energy Metabolism, first, Gastrointestinal Microbiome, Humans, lipids, Neoplasms, Obesity, oxysterols, review, Signal Transduction, Tumor Escape, Tumor Hypoxia, Tumor Microenvironment |
| Date Added | 2024/12/03 - 09:12:56 |
| Date Modified | 2024/12/03 - 09:12:56 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
