| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Liver Venous Deprivation Versus Portal Vein Embolization Before Major Hepatectomy for Colorectal Liver Metastases: A Retrospective Comparison of Short- and Medium-Term Outcomes |
| Creator | Cassese et al. |
| Author | Gianluca Cassese |
| Author | Roberto Ivan Troisi |
| Author | Salah Khayat |
| Author | Bachir Benoudifa |
| Author | Boris Guiu |
| Author | Fabrizio Panaro |
| Abstract | BACKGROUND: Liver venous deprivation (LVD) is a recent radiological technique performed to induce hypertrophy of the future liver remnant. Medium-term results of major hepatectomy after LVD have never been compared with the actual standard of care, portal vein embolization (PVE). METHODS: We retrospectively compared data from 33 consecutive patients who had undergone LVD (n?=?17) or PVE (n?=?16) prior to a right hemi-hepatectomy or right extended hepatectomy indicated for colorectal liver metastases (CRLM) between May 2015 and December 2019. RESULTS: The 1-year and 3-year overall survival (OS) rates in the LVD group were 81.3% (95% confidence interval [CI]: 72-90) and 54.7% (95% CI: 46-63), respectively, against 85% (95% CI: 69-101) and 77.4% (95% CI: 54-100) in the PVE group; the differences were not statistically significant (p?=?0.64). The median disease-free survival (DFS) rate was also comparable: 6 months (95% CI: 4-7) in the LVD group and 12 months (95% CI: 1.5-13) in the PVE group (p?=?0.29). The overall intra-operative and post-operative complication rates were similar between the two groups. The mean daily kinetic growth rate (KGR) was found to be higher after LVD than after PVE (0.2% vs. 0.1%, p?=?0.05; 10 cc/day vs. 4.8 cc/day, p?=?0.03), as was the mean increase in future liver remnant volume (FLR-V) (49% vs. 27%, p?=?0.01). CONCLUSIONS: The LVD technique is well tolerated in patients undergoing right hemi-hepatectomy or right extended hepatectomy for CRLM. When compared with the PVE technique, the LVD technique has similar peri-operative and medium-term outcomes, but higher KGR and FLR-V increase. |
| Publication | Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract |
| Volume | 27 |
| Issue | 2 |
| Pages | 296-305 |
| Date | 2023-02 |
| Journal Abbr | J Gastrointest Surg |
| Language | eng |
| DOI | 10.1007/s11605-022-05551-2 |
| ISSN | 1873-4626 |
| Short Title | Liver Venous Deprivation Versus Portal Vein Embolization Before Major Hepatectomy for Colorectal Liver Metastases |
| Library Catalog | PubMed |
| Extra | PMID: 36509901 PMCID: PMC9744374 |
| Tags | clinic, Colorectal Neoplasms, Embolization, Therapeutic, Hepatectomy, Humans, Liver, Liver Neoplasms, Major hepatectomy, Portal Vein, Portal vein embolization, Retrospective Studies, Treatment Outcome |
| Date Added | 2023/11/03 - 09:54:54 |
| Date Modified | 2024/03/01 - 09:41:52 |
| Notes and Attachments | Full Text (Attachment) PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
