| Abstract |
Summary
Purpose
Dual?energy X?ray absorptiometry (
DXA
) is used in clinical routine to determine areal bone mineral density (
aBMD
). However, it is not clear whether excessive fat mass or substantial weight loss modify the
aBMD
measurements. The aim of this study was to evaluate the effect of soft tissue composition on
aBMD
measured by
DXA
using a clinical model (i.e. sleeve gastrectomy:
SG
) that induces substantial body weight loss.
Methods
Areal bone mineral density and body composition (fat mass:
FM
and lean tissue mass:
LTM
) were determined by
DXA
in 41 obese patients (33 women, 80.5%) just before
SG
and 1 month later.
Results
One month after
SG
, mean weight loss was ?9.8 ± 2.6 kg, with a significant decrease in
LTM
and
FM
(kg) ranging from ?7.3% to ?9.5%. The relative variation in
aBMD
was increased at the lumbar spine (2.45 ± 3.44%) and decreased at the hip (?1.47 ± 2.28%), whereas no variation was observed for the whole body and radius. The variation in
aBMD
at the lumbar spine was inversely correlated with variations in weight, whole?body
FM
and trunk
FM
, but not LTM.
Conclusion
This study shows evidence of a potential effect of body composition, particularly
FM
, on
aBMD
. However, given the modest change in
aBMD
, which was close to the precision error of
aBMD
measurements, it appears that significant weight loss does not have a clinically significant impact on the evaluation of
aBMD
using DXA. |
Institut de Recherche en Cancérologie de
