| Added by | mollevi |
|---|---|
| Last modified by | Nathalie Bonnefoy |
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | CD39: A complementary target to immune checkpoints to counteract tumor-mediated immunosuppression |
| Creator | Bonnefoy et al. |
| Author | N. Bonnefoy |
| Author | J. Bastid |
| Author | G. Alberici |
| Author | A. Bensussan |
| Author | J. F. Eliaou |
| Abstract | We report that CD39-expressing-melanoma cells inhibited both T-cell proliferation and the generation of cytotoxic effectors in an adenosine-dependent manner, and that treatment with a CD39-blocking antibody alleviated tumor-mediated immunosuppression. Thus, blocking CD39 ectonucleotidase may represent a novel immunotherapeutic strategy to restore antitumor immunity. |
| Publication | Oncoimmunology |
| Volume | 4 |
| Pages | e1003015 |
| Date | May 2015 |
| Journal Abbr | Oncoimmunology |
| DOI | 10.1080/2162402X.2014.1003015 |
| ISSN | 2162-4011 (Print) 2162-4011 (Linking) |
| Tags | first-last-corresponding, review |
| Date Added | 2018/11/14 - 12:04:32 |
| Date Modified | 2019/05/28 - 21:46:13 |
| Notes and Attachments | (Note) (Note) 26155397 (Attachment) |
Institut de Recherche en Cancérologie de
