| Added by | standudu |
|---|---|
| Group name | EquipeAT |
| Item Type | Journal Article |
| Title | Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer |
| Creator | Chiavarina et al. |
| Author | Barbara Chiavarina |
| Author | Marie-Julie Nokin |
| Author | Justine Bellier |
| Author | Florence Durieux |
| Author | Noëlla Bletard |
| Author | Félicie Sherer |
| Author | Pierre Lovinfosse |
| Author | Olivier Peulen |
| Author | Laurine Verset |
| Author | Romain Dehon |
| Author | Pieter Demetter |
| Author | Andrei Turtoi |
| Author | Koji Uchida |
| Author | Serge Goldman |
| Author | Roland Hustinx |
| Author | Philippe Delvenne |
| Author | Vincent Castronovo |
| Author | Akeila Bellahcène |
| Abstract | Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies including cancer. All mammalian cells have an enzymatic defense against MG composed by glyoxalases GLO1 and GLO2 that converts MG to d-lactate. Colorectal cancer (CRC) is one of the most frequently occurring cancers with high morbidity and mortality. In this study, we used immunohistochemistry to examine the level of MG protein adducts, in a series of 102 CRC human tumors divided into four clinical stages. We consistently detected a high level of MG adducts and low GLO1 activity in high stage tumors compared to low stage ones suggesting a pro-tumor role for dicarbonyl stress. Accordingly, GLO1 depletion in CRC cells promoted tumor growth in vivo that was efficiently reversed using carnosine, a potent MG scavenger. Our study represents the first demonstration that MG adducts accumulation is a consistent feature of high stage CRC tumors. Our data point to MG production and detoxification levels as an important molecular link between exacerbated glycolytic activity and CRC progression. |
| Publication | International Journal of Molecular Sciences |
| Volume | 18 |
| Issue | 1 |
| Date | Jan 21, 2017 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms18010213 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | PMID: 28117708 PMCID: PMC5297842 |
| Tags | 18F-Fluorodeoxyglucose (18F-FDG), Adult, Aged, Animals, Carnosine, Cell Line, Tumor, Cell Proliferation, Chickens, Cohort Studies, colorectal cancer, Colorectal Neoplasms, Fluorodeoxyglucose F18, glyoxalase 1, Humans, Lactoylglutathione Lyase, MG-adducts, Middle Aged, Neoplasm Staging, original, Positron-Emission Tomography, Pyrimidines, Pyruvaldehyde, Stress, Physiological |
| Date Added | 2019/05/29 - 14:22:47 |
| Date Modified | 2019/05/29 - 14:29:16 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
