| Added by | mollevi |
|---|---|
| Last modified by | celine.gongora |
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Prostate cancer incidence on cystoprostatectomy specimens is directly linked to age: results from a multicentre study |
| Creator | Pignot et al. |
| Author | G. Pignot |
| Author | L. Salomon |
| Author | C. Lebacle |
| Author | Y. Neuzillet |
| Author | P. Lunardi |
| Author | P. Rischmann |
| Author | M. Zerbib |
| Author | C. Champy |
| Author | M. Roupret |
| Author | B. Peyronnet |
| Author | G. Verhoest |
| Author | T. Murez |
| Author | H. Quintens |
| Author | S. Larre |
| Author | N. Houede |
| Author | E. Comperat |
| Author | M. Soulie |
| Author | C. Pfister |
| Abstract | OBJECTIVE: To assess the incidence and age-related histopathological characteristics of incidentally diagnosed prostate cancer from specimens obtained via radical cystoprostatectomy (RCP) for muscle-invasive bladder cancer. PATIENTS AND METHODS: A retrospective review of the histopathological features of 2424 male patients who underwent a RCP for bladder cancer was done at eight centres between January 1996 and June 2012. No patient had preoperative suspicion of prostate cancer. Statistical analyses were performed in different age-related groups. RESULTS: Overall, prostate cancer was diagnosed in 518 men (21.4%). Incidences varied significantly according to age (5.2% in those aged <50 years to 30.5% in those aged >75 years, P < 0.001). Most of the prostate cancers were considered as 'non-aggressive', that is to say organ-confined (/=7 were significantly greater in older patients (P < 0.001). Apart from age, there were no preoperative predictive factors for 'non-aggressive' prostate-cancer status. At the end of the follow-up, only nine patients (1.7%) had biochemical recurrence of prostate cancer, and no preoperative predictive factors were identified. CONCLUSION: The rate of incidentally diagnosed prostate cancer from RCP specimens is approximately 20%, most of them being organ-confined and well-differentiated. The probability of having a 'non-aggressive' prostate cancer decreases in older men. |
| Publication | BJU Int |
| Volume | 115 |
| Pages | 87-93 |
| Date | Jan 2015 |
| Journal Abbr | BJU international |
| DOI | 10.1111/bju.12803 |
| ISSN | 1464-410X (Electronic) 1464-4096 (Linking) |
| Tags | Adult, Age Factors, Aged, Aged, 80 and over, clinic, Cohort Studies, Cystectomy, France/epidemiology, Humans, Incidence, Male, Middle Aged, Prognosis, Prostatectomy, Prostatic Neoplasms/*epidemiology/pathology/surgery, Retrospective Studies, Urinary Bladder Neoplasms/*epidemiology/pathology/surgery |
| Date Added | 2018/07/20 - 10:05:58 |
| Date Modified | 2019/05/14 - 15:15:21 |
| Notes and Attachments | (Note) (Note) 24825727 (Attachment) |
Institut de Recherche en Cancérologie de
