| Added by | mollevi |
|---|---|
| Last modified by | standudu |
| Group name | EquipeAT |
| Item Type | Journal Article |
| Title | High stromal transforming growth factor ?-induced expression is a novel marker of progression and poor prognosis in gastric cancer |
| Creator | Suzuki et al. |
| Author | Masaki Suzuki |
| Author | Takehiko Yokobori |
| Author | Navchaa Gombodorj |
| Author | Masakazu Yashiro |
| Author | Andrei Turtoi |
| Author | Tadashi Handa |
| Author | Kyoichi Ogata |
| Author | Tetsunari Oyama |
| Author | Ken Shirabe |
| Author | Hiroyuki Kuwano |
| Abstract | BACKGROUND AND OBJECTIVES: Transforming growth factor ?-induced (TGFBI) protein is a secreted extracellular matrix protein with conflicting roles in cancer, acting as a tumour suppressor and a promoter, which appears to be tissue specific. The role of TGFBI in gastric cancer (GC) remains unclear, which we aimed to investigate using the clinical samples as well as an in vitro coculture model of GC. METHODS: The clinical significance of TGFBI was assessed in 208 GC samples using immunohistochemistry. Molecular function of TGFBI in the GC cells was examined by small interfering RNA-mediated TGFBI downregulation in the gastric fibroblasts cocultured with the GC cells. RESULTS: TGFBI expression was localised mainly in the cancer stroma and not in the noncancerous gastric tissue or the GC cells. High TGFBI expression was significantly associated with poor prognosis and cancer progression. Downregulation of TGFBI in the cocultured gastric fibroblasts inhibited the invasion and migration abilities of the GC cells. CONCLUSIONS: High stromal TGFBI expression might be a useful predictive marker for poor prognosis in GC patients. Furthermore, TGFBI in the cancer stromal cells is a promising target for GC treatment. |
| Publication | Journal of Surgical Oncology |
| Volume | 118 |
| Issue | 6 |
| Pages | 966-974 |
| Date | Nov 2018 |
| Journal Abbr | J Surg Oncol |
| Language | eng |
| DOI | 10.1002/jso.25217 |
| ISSN | 1096-9098 |
| Library Catalog | PubMed |
| Extra | PMID: 30260476 |
| Tags | Aged, Biomarkers, Tumor, Cell Line, Tumor, Cell Movement, Coculture Techniques, Disease Progression, Extracellular Matrix Proteins, Female, gastric cancer, Gene Knockdown Techniques, Humans, Immunohistochemistry, Male, Middle Aged, original, Prognosis, RNA, Small Interfering, Stomach Neoplasms, stroma, Stromal Cells, transforming factor ?-induced, Transforming Growth Factor beta, Tumor Cells, Cultured |
| Date Added | 2019/01/18 - 16:11:01 |
| Date Modified | 2019/05/29 - 13:54:11 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
