Research
Epitranscriptomics & Cancer Adaptation : A.David

Activities

Our research work focuses on the contribution of post-transcriptional mechanisms on cancer cell adaptation, in particular RNA epigenetic & translational control.

More..

Zotero public

Added by mollevi
Group name EquipeMY
Item Type Journal Article
Title Second-Opinion Interpretations of Gynecologic Oncologic MRI Examinations by Sub-Specialized Radiologists Influence Patient Care
Creator Lakhman et al.
Author Yulia Lakhman
Author Melvin D'Anastasi
Author Maura Miccò
Author Chiara Scelzo
Author Hebert Alberto Vargas
Author Stephanie Nougaret
Author Ramon E. Sosa
Author Dennis S. Chi
Author Nadeem R. Abu-Rustum
Author Hedvig Hricak
Author Evis Sala
Abstract PURPOSE: To determine if second-opinion review of gynaecologic oncologic (GynOnc) magnetic resonance imaging (MRI) by sub-specialized radiologists impacts patient care. METHODS: 469 second-opinion MRI interpretations rendered by GynOnc radiologists were retrospectively compared to the initial outside reports. Two gynaecologic surgeons, blinded to the reports' origins, reviewed all cases with discrepancies between initial and second-opinion MRI reports and recorded whether these discrepancies would have led to a change in patient management defined as a change in treatment approach, counselling, or referral. Histopathology or minimum 6-month imaging follow-up were used to establish the diagnosis. RESULTS: Second-opinion review of GynOnc MRIs would theoretically have affected management in 94/469 (20 %) and 101/469 (21.5 %) patients for surgeons 1 and 2, respectively. Specifically, second-opinion review would have theoretically altered treatment approach in 71/469 (15.1 %) and 60/469 (12.8 %) patients for surgeons 1 and 2, respectively. According to surgeons 1 and 2, these treatment changes would have prevented unnecessary surgery in 35 (7.5 %) and 31 (6.6 %) patients, respectively, and changed surgical procedure type/extent in 19 (4.1 %) and 12 (2.5 %) patients, respectively. Second-opinion interpretations were correct in 103 (83 %) of 124 cases with clinically relevant discrepancies between initial and second-opinion reports. CONCLUSIONS: Expert second-opinion review of GynOnc MRI influences patient care. KEY POINTS: ? Outside gynaecologic oncologic MRI examinations are often submitted for a second-opinion review. ? One-fifth of MRIs had important discrepancies between initial and second-opinion interpretations. ? Second-opinion review of gynaecologic oncologic MRI is a valuable clinical service.
Publication European Radiology
Volume 26
Issue 7
Pages 2089-2098
Date Jul 2016
Journal Abbr Eur Radiol
Language eng
DOI 10.1007/s00330-015-4040-5
ISSN 1432-1084
Library Catalog PubMed
Extra PMID: 26494640 PMCID: PMC5527327
Tags Adolescent, Adult, Aged, Aged, 80 and over, clinic, Female, Genital Neoplasms, Female, Gynaecologic oncologic imaging, Humans, Magnetic Resonance Imaging, Middle Aged, Observer Variation, Patient Care, Radiologists, Referral and Consultation, Retrospective Studies, Second opinion, Subspecialty radiologists, Young Adult
Date Added 2018/11/13 - 17:35:30
Date Modified 2019/05/21 - 14:40:17


© Institut de Recherche en Cancérologie de Montpellier - 2011 - Tous droits réservés - Mentions légales - Connexion - Conception : ID Alizés