| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Magnetic Resonance-Guided Reirradiation for Local Recurrence within the Prostate or in the Prostate Bed: One-Year Clinical Results of a Prospective Registry Study |
| Creator | Michalet et al. |
| Author | Morgan Michalet |
| Author | Olivier Riou |
| Author | Jeremy Cottet-Moine |
| Author | Florence Castan |
| Author | Sophie Gourgou |
| Author | Simon Valdenaire |
| Author | Pierre Debuire |
| Author | Norbert Ailleres |
| Author | Roxana Draghici |
| Author | Marie Charissoux |
| Author | Carmen Llacer Moscardo |
| Author | Marie-Pierre Farcy-Jacquet |
| Author | Pascal Fenoglietto |
| Author | David Azria |
| Abstract | Around 33% of patients treated by EBRT or brachytherapy will present a biochemical recurrence. SBRT is a new option for the treatment of patients with local-only recurrence. MRgRT seems to be interesting for the treatment of these recurrences. This article presents the one-year late tolerance and biochemical recurrence-free survival results of a prospective registry study. Patients with intraprostatic (or in the prostate bed) recurrence were treated with 5 to 9 fractions (median dose of 30 Gy in 5 fractions) with the MRIdian® system. PSA level and toxicities were evaluated before treatment and at three, six and 12 months after treatment. Thirty-seven patients with a median age of 74.5 years old were treated between 21 October 2019 and 7 December 2020. Acute tolerance was excellent with no grade >2 toxicities. Twelve months after treatment, we observed an increase of grade 1?2 dysuria (46% vs. 13% before treatment) and grade 1 polyuria (73% vs. 7%). The six, nine and 12-months biochemical-recurrence free survival were 97.3%, 86.5% and 65.0%. Fifteen patients (40%) presented a biochemical recurrence. Nine of these 15 patients (60%) had a persistent disease within the treated volume. In conclusion, MRgRT is safe and has promising survival results. |
| Publication | Cancers |
| Volume | 14 |
| Issue | 8 |
| Pages | 1943 |
| Date | 2022-04-12 |
| Journal Abbr | Cancers (Basel) |
| Language | eng |
| DOI | 10.3390/cancers14081943 |
| ISSN | 2072-6694 |
| Short Title | Magnetic Resonance-Guided Reirradiation for Local Recurrence within the Prostate or in the Prostate Bed |
| Library Catalog | PubMed |
| Extra | Number: 8 PMID: 35454850 PMCID: PMC9030485 |
| Tags | clinic, first-last-coresponding, last, MRI-guided radiotherapy (MRgRT), reirradiation, stereotactic body radiotherapy (SBRT) |
| Date Added | 2023/11/23 - 12:48:25 |
| Date Modified | 2024/12/15 - 04:00:01 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
