| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | [Immune response and digestive cancers: Prognostic and therapeutic implications] |
| Creator | Bibeau et al. |
| Author | Frédéric Bibeau |
| Author | Céline Bazille |
| Author | Magali Svrcek |
| Author | Rémi Pierson |
| Author | Christine Lagorce-Pagès |
| Author | Romain Cohen |
| Author | Thierry André |
| Abstract | The aim of this article is to emphasize the impact of the immune response in digestive cancers, especially from colorectal (CRC) origin. In this setting, an adaptive lymphocytic infiltrate underlines the prognostic impact of the immune response, because it is associated to a favorable outcome. The next challenge will be to validate, in a prospective therapeutic trial, the integration of the immune response as decisional parameter for adjuvant therapy. The immune response is also a predictive parameter in microsatellite instable metastatic CRC, characterized by an adaptive lymphocytic infiltrate, leading to a very high response rate to immune therapies. However, prognostic and predictive biomarkers still need to be optimized in order to better select patients. These data are also valuable for digestive non-colorectal cancers, which are briefly analyzed. The methodology for the assessment of these prognostic and predictive biomarkers, which represents an important issue in precision medicine, is also discussed. |
| Publication | Annales De Pathologie |
| Volume | 37 |
| Issue | 1 |
| Pages | 111-116 |
| Date | Feb 2017 |
| Journal Abbr | Ann Pathol |
| Language | fre |
| DOI | 10.1016/j.annpat.2016.12.008 |
| ISSN | 0242-6498 |
| Short Title | [Immune response and digestive cancers |
| Library Catalog | PubMed |
| Extra | PMID: 28111038 |
| Tags | Adenocarcinoma, Biomarkers, Tumor, Cancers colorectaux, Cancers digestifs, Colorectal Neoplasms, Digestive cancer, Digestive System Neoplasms, Humans, Immune response, Immunohistochemistry, Immunotherapy, Lymphocytes, Tumor-Infiltrating, Microsatellite Instability, Mutation, Neoplasm Proteins, Precision Medicine, Prediction, Prognosis, Prognostic, Pronostic, Réponse immune, review, Transcriptome |
| Date Added | 2018/11/13 - 17:25:22 |
| Date Modified | 2019/05/21 - 13:38:03 |
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