| Added by | eric_julien |
|---|---|
| Group name | EquipeEJ |
| Item Type | Journal Article |
| Title | The dosage compensation complex shapes the conformation of the X chromosome in Drosophila |
| Creator | Grimaud and Becker |
| Author | Charlotte Grimaud |
| Author | Peter B. Becker |
| Abstract | The dosage compensation complex (DCC) in Drosophila globally increases transcription from the X chromosome in males to compensate for its monosomy. We discovered a male-specific conformation of the X chromosome that depends on the associations of high-affinity binding sites (HAS) of the DCC. The core DCC subunits MSL1-MSL2 are responsible for this male-specific organization. Contrary to emerging concepts, we found that neither DCC assembly nor the conformation of the male X chromosome are influenced by nuclear pore components. We propose that nuclear organization of HAS is central to the faithful distribution of the DCC along the X chromosome. |
| Publication | Genes & Development |
| Volume | 23 |
| Issue | 21 |
| Pages | 2490-2495 |
| Date | Nov 01, 2009 |
| Journal Abbr | Genes Dev. |
| Language | eng |
| DOI | 10.1101/gad.539509 |
| ISSN | 1549-5477 |
| Library Catalog | PubMed |
| Extra | PMID: 19884256 PMCID: PMC2779748 |
| Tags | Animals, Cell Nucleus, Dosage Compensation, Genetic, Drosophila melanogaster, Drosophila Proteins, Embryonic Development, Interphase, Male, Protein Binding, X Chromosome |
| Date Added | 2018/09/26 - 15:50:01 |
| Date Modified | 2018/09/26 - 15:50:01 |
Institut de Recherche en Cancérologie de
