| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancer |
| Creator | Colombo et al. |
| Author | Pierre-Emmanuel Colombo |
| Author | Michel Fabbro |
| Author | Charles Theillet |
| Author | Frédéric Bibeau |
| Author | Philippe Rouanet |
| Author | Isabelle Ray-Coquard |
| Abstract | Ovarian carcinoma is the most lethal gynaecologic malignancy. Despite wide initial sensibility to chemotherapy especially to platinum-based regimens, the vast majority of patients with advanced stages of the disease develop recurrences and subsequent resistance to treatments. Ovarian cancer is actually considered as a heterogeneous disease at the clinical, histological and molecular level. In this review, the mechanisms of intrinsic sensitivity or resistance to treatment, especially to platinum-based chemotherapy are considered with particular reference to the significance of tumour heterogeneity. The molecular features involved in acquired resistance are reviewed and the current hypotheses are discussed. In particular, potential disruptions of the DNA reparation pathways are highlighted. |
| Publication | Critical Reviews in Oncology/Hematology |
| Volume | 89 |
| Issue | 2 |
| Pages | 207-216 |
| Date | Feb 2014 |
| Journal Abbr | Crit. Rev. Oncol. Hematol. |
| Language | eng |
| DOI | 10.1016/j.critrevonc.2013.08.017 |
| ISSN | 1879-0461 |
| Library Catalog | PubMed |
| Extra | PMID: 24071502 |
| Tags | American Society of Clinical Oncology, Animals, Antineoplastic Agents, ARID1A, ASCO, AT-rich interactive domain 1A gene, ataxia telangiectasia and Rad3 related, ataxia telangiectasia mutated, ATM, ATR, B-RAF, base excision repair, BER, BRCA1/2, breast cancer gene 1 or 2, Carcinoma, Ovarian Epithelial, CCNE1, copper transporter 1, corresponding, CTR1, cyclin E1, DNA Repair, DNA repair pathways, Drug Resistance, Neoplasm, EGFR, epidermal growth factor receptor, ERCC1, excision repair cross-complementation group 1, FANCD2, Fanconi anaemia, complementation group D2, Female, FIGO, first, first-last-corresponding, gastro-intestinal stromal tumour, GIST, gluthatione S-transferase, GST, HER2, Heterogeneity, homologous recombination, HR, human epidermal growth factor receptor-2, Humans, International Federation of Gynecology and Obstetrics, K-RAS, MAPK, mitogen-activated protein kinases, Molecular subtypes, MRP2, multidrug resistance protein 2, Neoplasms, Glandular and Epithelial, NER, nucleotide excision repair, Organoplatinum Compounds, OS, Ovarian cancer, Ovarian Neoplasms, Ovary, overall survival, PARP, phosphatase and tensin homolog, poly ADP ribose polymerase, PTEN, relapse-free survival, Resistance, review, RFS, serous tubal intraepithelial carcinoma, STIC, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, v-raf murine sarcoma viral oncogene homolog B1, vascular endothelial growth factor, VEGF |
| Date Added | 2019/05/31 - 16:02:55 |
| Date Modified | 2022/08/01 - 16:05:51 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
