| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | 99mTc-mebrofenin hepatobiliary scintigraphy and volume metrics before liver preparation: correlations and discrepancies in non-cirrhotic patients |
| Creator | Guiu et al. |
| Author | Boris Guiu |
| Author | Emmanuel Deshayes |
| Author | Fabrizio Panaro |
| Author | Florian Sanglier |
| Author | Caterina Cusumano |
| Author | Astrid Herrerro |
| Author | Olivia Sgarbura |
| Author | Nicolas Molinari |
| Author | Christophe Cassinotto |
| Abstract | Background: Accurate identification of insufficient future liver remnant (FLR) is required to select patients for liver preparation and limit the risk of post-hepatectomy liver failure (PHLF). The objective of this study was to investigate the correlations and discrepancies between the most-commonly used FLR volume metrics and 99mTc-mebrofenin hepatobiliary scintigraphy (HBS). Methods: In 101 non-cirrhotic patients who underwent HBS before major hepatectomy, we retrospectively analyzed the correlations and discrepancies between FLR function and FLR volume metrics: actual percentage (FLRV%), standardized to body surface area (FLRV%BSA) and weight (FLRV%weight), and FLR to body weight ratio (FLRV-BWR). Results: Among 67 patients with FLR function ?2.69%/min/m2, PHLF was observed in none and 13 patients according to respectively 50-50 and ISGLS criteria. FLRV%, FLRV%BSA, FLRV%weight and FLRV-BWR significantly correlated with FLR function (P<0.001), with Spearman's correlation coefficients of 0.680, 0.704, 0.698, and 0.711, respectively. No difference was observed between the areas under the curve of FLRV%, FLRV%BSA, FLRV%weight and FLR-BWR (all P=ns). Overall, the percentages of patients misclassified by FLRV%, FLRV%BSA, FLRV%weight (thresholds: 30%) and FLR-BWR (threshold: 0.5) versus FLR function (threshold: 2.69%/min/m2) were 23.8% (95% CI: 15.9-33.3%), 18.8% (95% CI: 11.7-27.8%), 17.8% (95% CI: 11-26.7%), and 31.7% (95% CI: 22.8-41.7%), respectively. FLR volume metrics wrongly classified 1-13.9% of patients with sufficient FLR function (i.e., ?2.69%/min/m2), and 9.9-30.7% of patients with insufficient FLR function. FLRV-BWR was the most and the least reliable measure to identify patients with sufficient and insufficient FLR function, respectively. Conclusions: Despite significant correlations, the discrepancy rates between FLR volume and function metrics speaks in favor of implementing 99mTc-mebrofenin HBS in the work-up before liver preparation. |
| Publication | Annals of Translational Medicine |
| Volume | 9 |
| Issue | 9 |
| Pages | 795 |
| Date | 2021-05 |
| Journal Abbr | Ann Transl Med |
| Language | eng |
| DOI | 10.21037/atm-20-7372 |
| ISSN | 2305-5839 |
| Short Title | 99mTc-mebrofenin hepatobiliary scintigraphy and volume metrics before liver preparation |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 34268408 PMCID: PMC8246210 |
| Tags | clinic, CT-scan, Hepatectomy, mebrofenin |
| Date Added | 2021/08/06 - 17:52:02 |
| Date Modified | 2022/02/04 - 18:11:32 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
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