| Added by | mollevi |
|---|---|
| Last modified by | standudu |
| Group name | EquipePC |
| Item Type | Journal Article |
| Title | A multiparametric serum marker panel as a complementary test to mammography for the diagnosis of node-negative early-stage breast cancer and DCIS in young women |
| Creator | Lacombe et al. |
| Author | J. Lacombe |
| Author | A. Mange |
| Author | A. C. Bougnoux |
| Author | I. Prassas |
| Author | J. Solassol |
| Abstract | BACKGROUND: The sensitivity of mammography for the detection of small lesions, including node-negative early-stage (T1N0) primary breast cancer (PBC) and ductal carcinoma in situ (DCIS), is significantly decreased in young patients. From a clinical standpoint, an inconclusive mammogram reflects the inability of clinicians to confidently decide whether patients should be referred for biopsy or for follow-up with repeat imaging. METHODS: Specific ELISAs were developed for a panel of 13 well-recognized breast autoantigens (HSP60, FKBP52, PRDX2, PPIA, MUC1, GAL3, PAK2, P53, CCNB1, PHB2, RACK1, RUVBL1, and HER2). Circulating autoantibody levels were measured in a cohort of 396 serum samples from histologically confirmed DCIS (n = 87) or T1N0 PBC (n = 153) and healthy controls (n = 156). RESULTS: Individually, antibodies against CCNB1, FKBP52, GAL3, PAK2, PRDX2, PPIA, P53, and MUC1 demonstrated discriminatory power between breast cancer and healthy control groups. At 90% sensitivity, the overall combined specificity of the autoantibody serum screening test was 42%. Adjustment for higher sensitivities of 95% and 99% resulted in 30% and 21% specificities, respectively (33% and 18% in T1N0 PBC and 28% and 21% in DCIS). Finally, in patients with node-negative early-stage breast cancer younger than 50 years, the autoantibody assay exhibited 59% specificity with a fixed sensitivity at 90%. CONCLUSIONS: Our autoantibody panel allows accurate detection of early breast cancer and DCIS, notably in younger patients. IMPACT: Clinical assessment of this autoantibody panel displays a potential to facilitate clinical management of early-stage breast cancer detection in cases of inconclusive mammogram. |
| Publication | Cancer Epidemiol Biomarkers Prev |
| Volume | 23 |
| Pages | 1834-42 |
| Date | Sep 2014 |
| Journal Abbr | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology |
| DOI | 10.1158/1055-9965.EPI-14-0267 |
| ISSN | 1538-7755 (Electronic) 1055-9965 (Linking) |
| Tags | Adult, Aged, Autoantibodies/*blood, Breast Neoplasms/*blood/*diagnosis/pathology/radiography, Carcinoma, Intraductal, Noninfiltrating/*blood/*diagnosis/pathology/radiography, clinic, Early Detection of Cancer, Female, Humans, Lymphatic Metastasis, Mammography, Middle Aged, original, Tumor Markers, Biological/*blood |
| Date Added | 2018/11/14 - 12:07:50 |
| Date Modified | 2019/05/27 - 19:01:43 |
| Notes and Attachments | (Note) (Note) 24957886 (Attachment) |
Institut de Recherche en Cancérologie de
