| Added by | amaraver |
|---|---|
| Group name | EquipeAM |
| Item Type | Journal Article |
| Title | Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer |
| Creator | Middleton et al. |
| Author | Gary Middleton |
| Author | Cesare Gridelli |
| Author | Jean-Louis Pujol |
| Author | Martin Reck |
| Author | Rodryg Ramlau |
| Author | Barbara Parente |
| Author | Thierry Pieters |
| Author | Carla M. Visseren-Grul |
| Author | William J. John |
| Author | Annamaria Hayden Zimmermann |
| Author | Nadia Chouaki |
| Author | Luis Paz-Ares |
| Abstract | OBJECTIVES: To assess the effect of long-term pemetrexed maintenance therapy on patients' renal function. METHODS: In the PARAMOUNT phase III trial (NCT 00789373), pemetrexed was compared with placebo as maintenance treatment in advanced nonsquamous non-small-cell lung cancer patients who completed 4 cycles of pemetrexed plus cisplatin induction therapy. To evaluate changes in renal function during pemetrexed continuation maintenance treatment, we retrospectively analyzed changes in serum creatinine (sCr), treatment-emergent adverse events, dose delays and treatment discontinuations associated with impaired renal function. RESULTS: Creatinine clearance ?45?mL/min was required before the start of any cycle. Patients on pemetrexed maintenance had a significantly higher percentage maximum increase in sCr over baseline versus placebo for the range of ?10% to ?90% increase (p? |
| Publication | Current Medical Research and Opinion |
| Volume | 34 |
| Issue | 5 |
| Pages | 865-871 |
| Date | May 2018 |
| Journal Abbr | Curr Med Res Opin |
| Language | eng |
| DOI | 10.1080/03007995.2018.1439462 |
| ISSN | 1473-4877 |
| Short Title | Evaluation of changes in renal function in PARAMOUNT |
| Library Catalog | PubMed |
| Extra | PMID: 29424248 |
| Tags | clinic, Creatinine clearance, maintenance therapy, non-small-cell-lung cancer, renal toxicity, serum creatinine |
| Date Added | 2018/11/15 - 16:12:45 |
| Date Modified | 2019/05/16 - 10:34:17 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
