| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Deportalization, Venous Congestion, Venous Deprivation: Serial Measurements of Volumes and Functions on Morphofunctional 99mTc-Mebrofenin SPECT-CT |
| Creator | Piron et al. |
| Author | Lauranne Piron |
| Author | Emmanuel Deshayes |
| Author | Christophe Cassinotto |
| Author | Fabrizio Panaro |
| Author | Margaux Hermida |
| Author | Carole Allimant |
| Author | Eric Assenat |
| Author | Georges-Philippe Pageaux |
| Author | Nicolas Molinari |
| Author | Boris Guiu |
| Abstract | The objective was to assess the changes in regional volumes and functions under venous-impaired vascular conditions following liver preparation. Twelve patients underwent right portal vein embolization (PVE) (n = 5) or extended liver venous deprivation (eLVD, i.e., portal and right and middle hepatic veins embolization) (n = 7). Volume and function measurements of deportalized liver, venous-deprived liver and congestive liver were performed before and after PVE/eLVD at days 7, 14 and 21 using 99mTc-mebrofenin hepatobiliary scintigraphy with single-photon emission computed tomography and computed tomography (99mTc-mebrofenin SPECT-CT). Volume and function progressed independently in the deportalized liver (p = 0.47) with an early decrease in function (median -18.2% (IQR, -19.4--14.5) at day 7) followed by a decrease in volume (-19.3% (-22.6--14.4) at day 21). Volume and function progressed independently in the venous deprived liver (p = 0.80) with a marked and early decrease in function (-41.1% (-52.0--12.9) at day 7) but minimal changes in volume (-4.7% (-10.4-+3.9) at day 21). Volume and function progressed independently in the congestive liver (p = 0.21) with a gradual increase in volume (+43.2% (+38.3-+51.2) at day 21) that preceded a late and moderate increase in function at day 21 (+34.8% (-8.3-+46.6)), concomitantly to the disappearance of hypoattenuated congestive areas in segment IV (S4) on CT, initially observed in 6/7 patients after eLVD and represented 35.3% (22.2-46.4) of whole S4 volume. Liver volume and function progress independently whatever the vascular condition. Hepatic congestion from outflow obstruction drives volume increase but results in early impaired function. |
| Publication | Diagnostics (Basel, Switzerland) |
| Volume | 11 |
| Issue | 1 |
| Date | 2020-12-23 |
| Journal Abbr | Diagnostics (Basel) |
| Language | eng |
| DOI | 10.3390/diagnostics11010012 |
| ISSN | 2075-4418 |
| Short Title | Deportalization, Venous Congestion, Venous Deprivation |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 33374810 |
| Tags | clinic, interventional radiology, radionuclide imaging |
| Date Added | 2021/01/05 - 11:15:05 |
| Date Modified | 2021/05/07 - 14:11:42 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) PubMed entry (Attachment) |
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