| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Prognostic impact of extracranial disease control in HER2+ breast cancer-related brain metastases |
| Creator | Bottosso et al. |
| Author | Michele Bottosso |
| Author | Gaia Griguolo |
| Author | Léa Sinoquet |
| Author | Maria Cristina Guarascio |
| Author | Vittoria Aldegheri |
| Author | Federica Miglietta |
| Author | Grazia Vernaci |
| Author | Caterina Barbieri |
| Author | Fabio Girardi |
| Author | William Jacot |
| Author | Valentina Guarneri |
| Author | Amélie Darlix |
| Author | Maria Vittoria Dieci |
| Abstract | BACKGROUND: Brain metastases (BM) are common among HER2+ breast cancer (BC) and prognostic stratification is crucial for optimal management. BC-GPA score and subsequent refinements (modified-GPA, updated-GPA) recapitulate prognostic factors. Since none of these indexes includes extracranial disease control, we evaluated its prognostic value in HER2+ BCBM. METHODS: Patients diagnosed with HER2+ BCBM at Istituto Oncologico Veneto-Padova (2002-2021) and Montpellier Cancer Institute (2001-2015) were included as exploratory and validation cohorts, respectively. Extracranial disease control at BM diagnosis (no disease/stable disease/response vs. progressive disease) was evaluated. RESULTS: In the exploratory cohort of 113 patients (median OS 12.2 months), extracranial control (n?=?65, 57.5%) was significantly associated with better OS at univariate (median OS 17.7 vs. 8.7 months, p?=?0.005) and multivariate analysis after adjustment for BC-GPA (HR 0.61, 95% CI 0.39-0.94), modified-GPA (HR 0.64, 95% CI 0.42-0.98) and updated-GPA (HR 0.63, 95% CI 0.41-0.98). The prognostic impact of extracranial disease control (n?=?66, 56.4%) was then confirmed in the validation cohort (n?=?117) at univariate (median OS 20.2 vs. 9.1 months, p? |
| Publication | British Journal of Cancer |
| Volume | 128 |
| Issue | 7 |
| Pages | 1286-1293 |
| Date | 2023-03 |
| Journal Abbr | Br J Cancer |
| Language | eng |
| DOI | 10.1038/s41416-023-02153-w |
| ISSN | 1532-1827 |
| Library Catalog | PubMed |
| Extra | PMID: 36717671 PMCID: PMC10049979 |
| Tags | Brain Neoplasms, Breast Neoplasms, clinic, Female, Humans, Prognosis, Retrospective Studies |
| Date Added | 2023/10/16 - 15:27:32 |
| Date Modified | 2023/10/16 - 17:34:44 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
