Added by | standudu |
---|---|
Group name | EquipeCTCS |
Item Type | Journal Article |
Title | Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study |
Creator | Viala et al. |
Author | Marie Viala |
Author | Akiko Chiba |
Author | Simon Thezenas |
Author | Laure Delmond |
Author | Pierre-Jean Lamy |
Author | Sarah L. Mott |
Author | Mary C. Schroeder |
Author | Alexandra Thomas |
Author | William Jacot |
Abstract | BACKGROUND: There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associated with not attaining a pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) for operable breast cancer. We report the impact of VD on pCR and survival in an expanded cohort. METHODS: Patients from Iowa and Montpellier registries who had serum VD level measured before or during NAC were included. Vitamin D deficiency was defined as 20 ng/mL. Pathological complete response was defined as no residual invasive disease in the breast and lymph nodes. Survival was defined from the date of diagnosis to the date of relapse (PFS) or date of death (OS). RESULTS: The study included 327 women. Vitamin D deficiency was associated with the odds of not attaining pCR (p?=?0.04). Fifty-four patients relapsed and 52 patients died. In multivariate analysis, stage III disease, triple-negative (TN) subtype and the inability to achieve pCR were independently associated with inferior survival. Vitamin D deficiency was not significantly associated with survival in the overall sample; however a trend was seen in the TN (5-years PFS 60.4% vs. 72.3%, p?=?0.3), and in the hormone receptor positive /human epidermal growth factor receptor 2 negative (HER2-) subgroups (5-years PFS 89% vs 78%, p?=?0.056). CONCLUSION: Vitamin D deficiency is associated with the inability to reach pCR in breast cancer patients undergoing NAC. |
Publication | BMC cancer |
Volume | 18 |
Issue | 1 |
Pages | 770 |
Date | Jul 30, 2018 |
Journal Abbr | BMC Cancer |
Language | eng |
DOI | 10.1186/s12885-018-4686-x |
ISSN | 1471-2407 |
Short Title | Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer |
Library Catalog | PubMed |
Extra | PMID: 30060745 PMCID: PMC6066931 |
Tags | clinic, Neo-adjuvant breast cancer, pCR, stan, Vitamin D |
Date Added | 2018/11/14 - 15:24:24 |
Date Modified | 2019/05/14 - 20:00:21 |
Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |