| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | Diversity and convergence in the mechanisms establishing L/R asymmetry in metazoa |
| Creator | Coutelis et al. |
| Author | Jean-Baptiste Coutelis |
| Author | Nicanor González-Morales |
| Author | Charles Géminard |
| Author | Stéphane Noselli |
| Abstract | Differentiating left and right hand sides during embryogenesis represents a major event in body patterning. Left-Right (L/R) asymmetry in bilateria is essential for handed positioning, morphogenesis and ultimately the function of organs (including the brain), with defective L/R asymmetry leading to severe pathologies in human. How and when symmetry is initially broken during embryogenesis remains debated and is a major focus in the field. Work done over the past 20 years, in both vertebrate and invertebrate models, has revealed a number of distinct pathways and mechanisms important for establishing L/R asymmetry and for spreading it to tissues and organs. In this review, we summarize our current knowledge and discuss the diversity of L/R patterning from cells to organs during evolution. |
| Publication | EMBO reports |
| Volume | 15 |
| Issue | 9 |
| Pages | 926-937 |
| Date | Sep 2014 |
| Journal Abbr | EMBO Rep. |
| Language | eng |
| DOI | 10.15252/embr.201438972 |
| ISSN | 1469-3178 |
| Library Catalog | PubMed |
| Extra | PMID: 25150102 PMCID: PMC4198036 |
| Tags | original |
| Date Added | 2019/05/14 - 12:11:29 |
| Date Modified | 2024/09/30 - 01:36:05 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) |
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