| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | Mechanical Control of Cell Migration by the Metastasis Suppressor Tetraspanin CD82/KAI1 |
| Creator | Ordas et al. |
| Author | Laura Ordas |
| Author | Luca Costa |
| Author | Anthony Lozano |
| Author | Christopher Chevillard |
| Author | Alexia Calovoulos |
| Author | Diala Kantar |
| Author | Laurent Fernandez |
| Author | Lucie Chauvin |
| Author | Patrice Dosset |
| Author | Christine Doucet |
| Author | Lisa Heron-Milhavet |
| Author | Elena Odintsova |
| Author | Fedor Berditchevski |
| Author | Pierre-Emmanuel Milhiet |
| Abstract | The plasma membrane is a key actor of cell migration. For instance, its tension controls persistent cell migration and cell surface caveolae integrity. Then, caveolae constituents such as caveolin-1 can initiate a mechanotransduction loop that involves actin- and focal adhesion-dependent control of the mechanosensor YAP to finely tune cell migration. Tetraspanin CD82 (also named KAI-1) is an integral membrane protein and a metastasis suppressor. Its expression is lost in many cancers including breast cancer. It is a strong inhibitor of cell migration by a little-known mechanism. We demonstrated here that CD82 controls persistent 2D migration of EGF-induced single cells, stress fibers and focal adhesion sizes and dynamics. Mechanistically, we found that CD82 regulates membrane tension, cell surface caveolae abundance and YAP nuclear translocation in a caveolin-1-dependent manner. Altogether, our data show that CD82 controls 2D cell migration using membrane-driven mechanics involving caveolin and the YAP pathway. |
| Publication | Cells |
| Volume | 10 |
| Issue | 6 |
| Pages | 1545 |
| Date | 2021-06-18 |
| Journal Abbr | Cells |
| Language | eng |
| DOI | 10.3390/cells10061545 |
| ISSN | 2073-4409 |
| Library Catalog | PubMed |
| Extra | PMID: 34207462 |
| Tags | actin, caveolins, cell migration, focal adhesions, mechanotransduction, original, phd, plasma membrane, tetraspanins, YAP |
| Date Added | 2021/07/03 - 11:32:53 |
| Date Modified | 2024/09/30 - 01:34:53 |
| Notes and Attachments | Full Text (Attachment) Full Text (Attachment) PubMed entry (Attachment) |
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