| Added by | lklinares |
|---|---|
| Group name | EquipeLL |
| Item Type | Journal Article |
| Title | ?133p53? isoform pro-invasive activity is regulated through an aggregation-dependent mechanism in cancer cells |
| Creator | Arsic et al. |
| Author | Nikola Arsic |
| Author | Tania Slatter |
| Author | Gilles Gadea |
| Author | Etienne Villain |
| Author | Aurelie Fournet |
| Author | Marina Kazantseva |
| Author | Nathalie Sibille |
| Author | Martial Seveno |
| Author | Sylvain de Rossi |
| Author | Sunali Mehta |
| Author | Serge Urbach |
| Author | Jean-Christophe Bourdon |
| Author | Andrey V. Kajava |
| Author | Antony Braithwaite |
| Author | Pierre Roux |
| Abstract | The p53 isoform, ?133p53?, is critical in promoting cancer. Here we report that ?133p53? activity is regulated through an aggregation-dependent mechanism. ?133p53? aggregates were observed in cancer cells and tumour biopsies. The ?133p53? aggregation depends on association with interacting partners including p63 family members or the CCT chaperone complex. Depletion of the CCT complex promotes accumulation of ?133p53? aggregates and loss of ?133p53? dependent cancer cell invasion. In contrast, association with p63 family members recruits ?133p53? from aggregates increasing its intracellular mobility. Our study reveals novel mechanisms of cancer progression for p53 isoforms which are regulated through sequestration in aggregates and recruitment upon association with specific partners like p63 isoforms or CCT chaperone complex, that critically influence cancer cell features like EMT, migration and invasion. |
| Publication | Nature Communications |
| Volume | 12 |
| Issue | 1 |
| Pages | 5463 |
| Date | 2021-09-15 |
| Journal Abbr | Nat Commun |
| Language | eng |
| DOI | 10.1038/s41467-021-25550-2 |
| ISSN | 2041-1723 |
| Library Catalog | PubMed |
| Extra | PMID: 34526502 PMCID: PMC8443592 |
| Tags | Animals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, MCF-7 Cells, Mice, Models, Molecular, Mutation, Neoplasm Invasiveness, Neoplasms, original, Protein Aggregates, Protein Aggregation, Pathological, Protein Conformation, Protein Isoforms, Protein Unfolding, Tumor Suppressor Protein p53 |
| Date Added | 2024/12/03 - 09:12:56 |
| Date Modified | 2024/12/03 - 09:12:56 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
