| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Anti-PD-1 for the treatment of advanced cutaneous squamous cell carcinoma in elderly patients: a French multicenter retrospective survey |
| Creator | Samaran et al. |
| Author | Quentin Samaran |
| Author | Romain Samaran |
| Author | Ernestine Ferreira |
| Author | Naeda Haddad |
| Author | Antoine Fottorino |
| Author | Hervé Maillard |
| Author | Brigitte Dreno |
| Author | Nicolas Meyer |
| Author | David Azria |
| Author | Eve Maubec |
| Author | Caroline Gaudy-Marqueste |
| Author | Nicolas Molinari |
| Author | Pierre-Emmanuel Stoebner |
| Author | Olivier Dereure |
| Abstract | BACKGROUND: Anti-PD1 agents are currently recommended as first-line treatment in advanced cutaneous squamous cell carcinoma (acSCC) by updated European guidelines. Although acSCC frequently affects elderly patients with multiple comorbidities, this subset of patients is often excluded of registration clinical trials. PURPOSE: To assess anti-PD-1 efficacy and safety in elderly acSCC patients in real-life conditions and describe this specific population with oncogeriatric evaluation tools. METHODS: A multicenter retrospective study including acSCC patients at least 70 years old treated with PD-1 inhibitors was conducted in French referral centers. The primary endpoint was the overall response rate (ORR). Secondary endpoints included safety data, time to response (TTR), duration of response (DOR), overall survival (OS), and progression-free survival (PFS). RESULTS: 63 patients were included. ORR was 57.1% (95% CI 44.0-69.5), median TTR and DOR were 3 and 5.5 months respectively. Median OS was not reached (95% CI 12.5 months-not reached) at data cut-off after a median follow-up of 8 months while median PFS was 8 months. (95% CI 5 months-not reached). Grade 3-5 adverse effects occurred in 47.6% of patients. 41.3% of patients experienced degradation of ECOG performance status during anti-PD-1 treatment. Nutritional state worsened in 27% of patients and 57.1% lost weight during treatment. CONCLUSION: In this particular subset of acSCC patients PD-1 inhibitors obtain results similar to those obtained in younger populations included in pivotal clinical trials, with acceptable safety. A specific oncogeriatric evaluation at treatment initiation and during follow-up appears important in this setting most notably to help manage toxicity. |
| Publication | Journal of Cancer Research and Clinical Oncology |
| Volume | 149 |
| Issue | 7 |
| Pages | 3549-3562 |
| Date | 2023-07 |
| Journal Abbr | J Cancer Res Clin Oncol |
| Language | eng |
| DOI | 10.1007/s00432-022-04246-0 |
| ISSN | 1432-1335 |
| Short Title | Anti-PD-1 for the treatment of advanced cutaneous squamous cell carcinoma in elderly patients |
| Library Catalog | PubMed |
| Extra | Number: 7 PMID: 35962286 PMCID: PMC9374288 |
| Tags | Aged, Aged (MeSH), Anti-PD-1, Antineoplastic Agents, Immunological, Carcinoma, Squamous Cell, clinic, Cutaneous squamous cell carcinoma, Humans, Immunotherapy (MeSH), Retrospective Studies, Skin Neoplasms, Skin neoplasms (MeSH) |
| Date Added | 2023/11/23 - 12:48:41 |
| Date Modified | 2023/11/23 - 12:48:41 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
