| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | The myosin ID pathway and left-right asymmetry in Drosophila |
| Creator | Géminard et al. |
| Author | Charles Géminard |
| Author | Nicanor González-Morales |
| Author | Jean-Baptiste Coutelis |
| Author | Stéphane Noselli |
| Abstract | Drosophila is a classical model to study body patterning, however left-right (L/R) asymmetry had remained unexplored, until recently. The discovery of the conserved myosin ID gene as a major determinant of L/R asymmetry has revealed a novel L/R pathway involving the actin cytoskeleton and the adherens junction. In this process, the HOX gene Abdominal-B plays a major role through the control of myosin ID expression and therefore symmetry breaking. In this review, we present organs and markers showing L/R asymmetry in Drosophila and discuss our current understanding of the underlying molecular genetic mechanisms. Drosophila represents a valuable model system revealing novel strategies to establish L/R asymmetry in invertebrates and providing an evolutionary perspective to the problem of laterality in bilateria. |
| Publication | Genesis (New York, N.Y.: 2000) |
| Volume | 52 |
| Issue | 6 |
| Pages | 471-480 |
| Date | Jun 2014 |
| Journal Abbr | Genesis |
| Language | eng |
| DOI | 10.1002/dvg.22763 |
| ISSN | 1526-968X |
| Library Catalog | PubMed |
| Extra | PMID: 24585718 |
| Tags | first, original |
| Date Added | 2019/05/14 - 12:12:25 |
| Date Modified | 2024/09/30 - 01:36:07 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
