| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Outcomes of patients with HER2-negative metastatic breast cancer after platinum- and non-platinum-based first-line chemotherapy among patients with and without pathogenic germline BRCA1/2 mutations |
| Creator | Jacot et al. |
| Author | William Jacot |
| Author | Cécile Vicier |
| Author | Audrey Mailliez |
| Author | Luc Cabel |
| Author | Christelle Levy |
| Author | Anne Patsouris |
| Author | Isabelle Desmoulins |
| Author | Lionel Uwer |
| Author | Mathieu Robain |
| Author | Olivier Caron |
| Author | Olivier Tredan |
| Author | Thomas Filleron |
| Author | Jean-Sébastien Frenel |
| Author | Suzette Delaloge |
| Abstract | BACKGROUND: The efficacy and added benefit of platinum-based chemotherapy (PtCT) for metastatic breast cancer (MBC) remain unclear in patients with and without germline BRCA1 or BRCA2 mutations (gBRCA1/2m and gBRCA1/2wt, respectively). METHODS: We selected from the French national real-world multicentre ESME cohort (2008-2016) all patients with HER2-negative MBC with known gBRCA1/2 status at first-line chemotherapy initiation. Using multivariable Cox models, we compared the outcome (progression-free (PFS) and overall survival (OS)) of first-line PtCT and non-PtCT regimens based on the patients' gBRCA1/2 status and tumour subtype. RESULTS: Patients who received PtCT had more aggressive tumour features. In the multivariable analysis, first-line PtCT was associated with better adjusted PFS and OS in gBRCA1/2m carriers (N?=?300), compared with non-PtCT (HR 0.54, 95% CI 0.4-0.73, P? |
| Publication | British Journal of Cancer |
| Volume | 127 |
| Issue | 11 |
| Pages | 1963-1973 |
| Date | 2022-11 |
| Journal Abbr | Br J Cancer |
| Language | eng |
| DOI | 10.1038/s41416-022-02003-1 |
| ISSN | 1532-1827 |
| Library Catalog | PubMed |
| Extra | PMID: 36207609 PMCID: PMC9681869 |
| Tags | Antineoplastic Agents, BRCA1 Protein, Breast Neoplasms, clinic, Female, Germ Cells, Humans, Mutation, Platinum |
| Date Added | 2023/10/16 - 15:33:44 |
| Date Modified | 2023/10/16 - 17:40:50 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
