| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Cytoplasmic and Nuclear Forms of Thyroid Hormone Receptor ?1 Are Inversely Associated with Survival in Primary Breast Cancer |
| Creator | Shao et al. |
| Author | Wanting Shao |
| Author | Christina Kuhn |
| Author | Doris Mayr |
| Author | Nina Ditsch |
| Author | Magdalena Kailuweit |
| Author | Verena Wolf |
| Author | Nadia Harbeck |
| Author | Sven Mahner |
| Author | Udo Jeschke |
| Author | Vincent Cavaillès |
| Author | Sophie Sixou |
| Abstract | The aim of this study was to investigate the expression of thyroid hormone receptor ?1 (THR?1) by immunohistochemistry in breast cancer (BC) tissues and to correlate the results with clinico-biological parameters. In a well-characterized cohort of 274 primary BC patients, THR?1 was widely expressed with a predominant nuclear location, although cytoplasmic staining was also frequently observed. Both nuclear and cytoplasmic THR?1 were correlated with high-risk BC markers such as human epidermal growth factor receptor 2 (HER2), Ki67 (also known as MKI67), prominin-1 (CD133), and N-cadherin. Overall survival analysis demonstrated that cytoplasmic THR?1 was correlated with favourable survival (p = 0.015), whereas nuclear THR?1 had a statistically significant correlation with poor outcome (p = 0.038). Interestingly, in our cohort, nuclear and cytoplasmic THR?1 appeared to be independent markers either for poor (p = 0.0004) or for good (p = 0.048) prognosis, respectively. Altogether, these data indicate that the subcellular expression of THR?1 may play an important role in oncogenesis. Moreover, the expression of nuclear THR?1 is a negative outcome marker, which may help to identify high-risk BC subgroups. |
| Publication | International Journal of Molecular Sciences |
| Volume | 21 |
| Issue | 1 |
| Pages | E330 |
| Date | 2020-01-03 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms21010330 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | PMID: 31947762 PMCID: PMC6981495 |
| Tags | Adult, Aged, Aged, 80 and over, breast cancer, Breast Neoplasms, Cell Nucleus, clinic, Cytoplasm, Female, Humans, Ki-67 Antigen, Middle Aged, overall survival, Prognosis, Receptor, ErbB-2, subcellular localization, Survival Analysis, thyroid hormone receptor beta 1, Thyroid Hormone Receptors beta |
| Date Added | 2021/09/01 - 17:11:35 |
| Date Modified | 2021/09/01 - 17:27:43 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
