| Added by | celine.gongora |
|---|---|
| Group name | EquipeCG |
| Item Type | Journal Article |
| Title | Epicure: a European epidemiological study of patients with an advanced or metastatic Urothelial Carcinoma (UC) having progressed to a platinum-based chemotherapy |
| Creator | Houédé et al. |
| Author | G. Locker |
| Author | C. Lucas |
| Author | H. Soto Parra |
| Author | U. Basso |
| Author | D. Spaeth |
| Author | R. Tambaro |
| Author | L. Basterretxea |
| Author | F. Morelli |
| Author | C. Theodore |
| Author | L. Lusuardi |
| Author | N. Lainez |
| Author | A. Guillot |
| Author | G. Tonini |
| Author | J. Bielle |
| Author | X. Garcia Del Muro |
| Abstract | BACKGROUND: Platinum-based systemic chemotherapy is considered the backbone for management of advanced urothelial carcinomas. However there is a lack of real world data on the use of such chemotherapy regimens, on patient profiles and on management after treatment failure. METHODS: Fifty-one randomly selected physicians from 4 European countries registered 218 consecutive patients in progression or relapse following a first platinum-based chemotherapy. Patient characteristics, tumor history and treatment regimens, as well as the considerations of physicians on the management of urothelial carcinoma were recorded. RESULTS: A systemic platinum-based regimen had been administered as the initial chemotherapy in 216 patients: 15 in the neoadjuvant setting, 61 in adjuvant therapy conditions, 137 in first-line advanced setting and 3 in other conditions. Of these patients, 76 (35 %) were initially considered as cisplatin-unfit, mainly because of renal impairment (52 patients). After platinum failure, renal impairment was observed in 44 % of patients, ECOG Performance Status???2 in 17 %, hemoglobinemia?30 % patients). The most frequent all-settings second anticancer therapy regimen was vinflunine (70 % of single-agent and 42 % of all subsequent treatments), the main reasons evoked by physicians (>1 out of 4) being survival benefit, safety and phase III evidence. CONCLUSION: In this daily practice experience, a majority of patients with urothelial carcinoma previously treated with a platinum-based therapy received a second chemotherapy regimen, most often a single agent after an initial chemotherapy in the advanced setting and preferably a cytotoxic combination after a neoadjuvant or adjuvant chemotherapy. Performance Status and prior response to chemotherapy were the main drivers of further treatment decisions. |
| Publication | BMC cancer |
| Volume | 16 |
| Issue | 1 |
| Pages | 752 |
| Date | 09 23, 2016 |
| Journal Abbr | BMC Cancer |
| Language | eng |
| DOI | 10.1186/s12885-016-2782-3 |
| ISSN | 1471-2407 |
| Short Title | Epicure |
| Library Catalog | PubMed |
| Extra | PMID: 27664126 PMCID: PMC5035464 |
| Tags | Aged, Aged, 80 and over, Anemia, Bladder cancer, Cisplatinum, clinic, Disease Progression, Epidemiology, Europe, Female, first, Humans, Kidney Diseases, Liver Neoplasms, Male, Metastatic, Neoplasm Metastasis, Pierre Fabre, Platinum, Practice, Practice Guidelines as Topic, Second-line, Treatment Failure, Urinary Bladder Neoplasms, Urothelial carcinoma, Urothelium, Vinflunine |
| Date Added | 2019/05/14 - 12:21:21 |
| Date Modified | 2019/10/24 - 16:17:51 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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