| Added by | JPPOUGET |
|---|---|
| Group name | EquipeJPP |
| Item Type | Journal Article |
| Title | Comparison of prone and supine positioning for breast cancer radiotherapy using REQUITE data: dosimetry, acute and two years physician and patient-reported outcomes |
| Creator | Vakaet et al. |
| Author | Vincent Vakaet |
| Author | Pieter Deseyne |
| Author | Renée Bultijnck |
| Author | Giselle Post |
| Author | Catharine West |
| Author | David Azria |
| Author | Marie-Pierre Farcy-Jacquet |
| Author | Barry Rosenstein |
| Author | Sheryl Green |
| Author | Elena Sperk |
| Author | Marlon Veldwijk |
| Author | Carsten Herskind |
| Author | Maria Carmen De Santis |
| Author | Tiziana Rancati |
| Author | Tommaso Giandini |
| Author | Jenny Chang-Claude |
| Author | Petra Seibold |
| Author | Maarten Lambrecht |
| Author | Caroline Weltens |
| Author | Hilde Janssens |
| Author | Ana Vega |
| Author | Maria Begoña Taboada-Valladares |
| Author | Miguel Elías Aguado-Barrera |
| Author | Victoria Reyes |
| Author | Manuel Altabas |
| Author | Sara Gutiérrez-Enríquez |
| Author | Christel Monten |
| Author | Hans Van Hulle |
| Author | Liv Veldeman |
| Abstract | OBJECTIVE: Most patients receive whole breast radiotherapy in a supine position. However, two randomised trials showed lower acute toxicity in prone position. Furthermore, in most patients, prone positioning reduced doses to the organs at risk. To confirm these findings, we compared toxicity outcomes, photographic assessment, and dosimetry between both positions using REQUITE data. METHODS: REQUITE is an international multi-centre prospective observational study that recruited 2069 breast cancer patients receiving radiotherapy. Data on toxicity, health-related quality of life (HRQoL), and dosimetry were collected, as well as a photographic assessment. A matched case control analysis compared patients treated prone (n?=?268) versus supine (n?=?493). Exact matching was performed for the use of intensity-modulated radiotherapy, boost, lymph node irradiation, chemotherapy and fractionation, and the nearest neighbour for breast volume. Primary endpoints were dermatitis at the end of radiotherapy, and atrophy and cosmetic outcome by photographic assessment at two?years. RESULTS: At the last treatment fraction, there was no significant difference in dermatitis (p?=?.28) or any HRQoL domain, but prone positioning increased the risk of breast oedema (p? |
| Publication | Acta Oncologica (Stockholm, Sweden) |
| Volume | 62 |
| Issue | 9 |
| Pages | 1036-1044 |
| Date | 2023-09 |
| Journal Abbr | Acta Oncol |
| Language | eng |
| DOI | 10.1080/0284186X.2023.2240486 |
| ISSN | 1651-226X |
| Short Title | Comparison of prone and supine positioning for breast cancer radiotherapy using REQUITE data |
| Library Catalog | PubMed |
| Extra | Number: 9 PMID: 37548182 |
| Tags | clinic, health-related quality of life, orginal, radiotherapy toxicity |
| Date Added | 2023/11/23 - 12:48:41 |
| Date Modified | 2023/11/23 - 12:48:41 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
