| Added by | Nathalie Bonnefoy |
|---|---|
| Group name | EquipeNB |
| Item Type | Journal Article |
| Title | Single-cell high-dimensional imaging mass cytometry: one step beyond in oncology |
| Creator | Glasson et al. |
| Author | Yaël Glasson |
| Author | Laure-Agnès Chépeaux |
| Author | Anne-Sophie Dumé |
| Author | Virginie Lafont |
| Author | Julien Faget |
| Author | Nathalie Bonnefoy |
| Author | Henri-Alexandre Michaud |
| Abstract | Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial, stromal, and immune) cell types constantly interact. Importantly, the abundance, localization, and functional orientation of each cell component within the tumor microenvironment vary significantly over time and in response to treatment. Such intratumoral heterogeneity influences the tumor course and its sensitivity to treatments. Recently, high-dimensional imaging mass cytometry (IMC) has been developed to explore the tumor ecosystem at the single-cell level. In the last years, several studies demonstrated that IMC is a powerful tool to decipher the tumor complexity. In this review, we summarize the potential of this technology and how it may be useful for cancer research (from preclinical to clinical studies). |
| Publication | Seminars in Immunopathology |
| Volume | 45 |
| Issue | 1 |
| Pages | 17-28 |
| Date | 2023-01 |
| Journal Abbr | Semin Immunopathol |
| Language | eng |
| DOI | 10.1007/s00281-022-00978-w |
| ISSN | 1863-2300 |
| Short Title | Single-cell high-dimensional imaging mass cytometry |
| Library Catalog | PubMed |
| Extra | PMID: 36598557 PMCID: PMC9812013 |
| Tags | corresponding, Ecosystem, first, Humans, Hyperion Imaging System, Image Cytometry, Imaging mass cytometry, last, MIBI-TOF, Neoplasms, review |
| Date Added | 2023/11/15 - 10:25:45 |
| Date Modified | 2023/11/15 - 17:26:12 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
