| Added by | Cavailles |
|---|---|
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | Prognostic relevance of RIP140 and ER? expression in unifocal versus multifocal breast cancers: a preliminary report |
| Creator | Müller et al. |
| Author | Katharina Müller |
| Author | Sophie Sixou |
| Author | Christina Kuhn |
| Author | Doris Mayr |
| Author | Nina Ditsch |
| Author | Tobias Weissenbacher |
| Author | Nadia Harbeck |
| Author | Sven Mahner |
| Author | Vincent Cavaillès |
| Author | Udo Jeschke |
| Abstract | The aim of this study was to investigate the expression of two nuclear receptor transcriptional coregulators, namely RIP140 (receptor-interacting protein of 140 kDa) and LCoR (ligand-dependent corepressor) in unifocal versus multifocal breast cancers. The expression of these two proteins was analyzed by immunohistochemistry in a matched-pair cohort of 21 unifocal and 21 multifocal breast tumors. The expression of the two estrogen receptors (ER? and ER?) was studied in parallel. RIP140 and LCoR levels appeared lower in unifocal tumors compared to multifocal samples (decreased of immune-reactive scores and reduced number of high expressing cells). In both tumor types, RIP140 and LCoR expression was correlated with each other and with expression of ER?. Very interestingly, the expression of RIP140, LCoR, and ER? was inversely correlated with overall survival only for the unifocal group. The negative correlation with overall and recurrence free survival was more pronounced in patients whose unifocal tumors expressed high levels of both RIP140 and ER?. Altogether, this preliminary report indicates that the ER?/RIP140 signaling is altered in unifocal breast cancers and correlated with patient outcome. Further investigation is needed to decipher the molecular mechanisms and the biological relevance of this deregulation. |
| Publication | International Journal of Molecular Sciences |
| Volume | 20 |
| Issue | 2 |
| Pages | 418 |
| Date | Jan 18, 2019 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms20020418 |
| ISSN | 1422-0067 |
| Short Title | Prognostic relevance of RIP140 and ER? expression in unifocal versus multifocal breast cancers |
| Library Catalog | PubMed |
| Extra | PMID: 30669416 PMCID: PMC6359229 |
| Tags | Adult, Aged, Biomarkers, Tumor, breast cancer, Breast Neoplasms, Estrogen Receptor beta, estrogen receptors, Female, Gene Expression, Humans, Immunohistochemistry, Kaplan-Meier Estimate, LCoR, Middle Aged, Neoplasm Grading, Neoplasm Staging, Nuclear Receptor Interacting Protein 1, original, Prognosis, RIP140, Tumor Burden, tumor focality |
| Date Added | 2019/05/16 - 11:15:33 |
| Date Modified | 2019/05/17 - 11:05:11 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
