| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Evaluation of the environmental contamination and exposure risk in medical/non-medical staff after oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy |
| Creator | Larroque et al. |
| Author | Marion Larroque |
| Author | Carine Arnaudguilhem |
| Author | Brice Bouyssiere |
| Author | Nabila Bouazza |
| Author | Marta Jarlier |
| Author | Sonia Boulabas |
| Author | Sandra Mounicou |
| Author | Olivia Sgarbura |
| Abstract | Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a technique to directly deliver chemotherapeutic drugs in the abdomen for the treatment of peritoneal metastases. Pressurization improves the treatment efficacy but increases the risk of exposure for the medical/non-medical staff who can be exposed by dermal or ocular contact, or inhalation of aerosols containing the cytotoxic drugs. The aim of this study was to evaluate the risk of exposure for the medical/non-medical staff (nurses, surgeons, anaesthesiologists and cleaning personnel; n = 13) during PIPAC with oxaliplatin performed according to the protocol recommended in France. Blood samples were collected 1 h before and immediately after PIPAC, and urine samples 1 h before, and then 3 h and the morning after PIPAC. In the control, non-exposed group (n = 7), only one urine and blood sample were collected. Surface contamination in the operating room was assessed in water- and Surfanios-impregnated wipe samples. The total elemental platinum in each sample was quantified by inductively coupled plasma mass spectrometry, using a method adapted to quantify trace amounts (ng.L-1) in very low volumes (100 ?l). No surface contamination was detected. Although 25% of urine samples in the exposed group contained platinum, no statistical difference was observed in urine and plasma samples collected before and after PIPAC and with the control group samples. These findings suggest that the French PIPAC protocol does not increase the risk of exposure to platinum in all staff categories involved. This protocol could be considered in future occupational policies and consensus statements. Trial registration: NCT04014426. |
| Publication | Toxicology and Applied Pharmacology |
| Volume | 429 |
| Pages | 115694 |
| Date | 2021-08-21 |
| Journal Abbr | Toxicol Appl Pharmacol |
| Language | eng |
| DOI | 10.1016/j.taap.2021.115694 |
| ISSN | 1096-0333 |
| Library Catalog | PubMed |
| Extra | 00000 PMID: 34428445 |
| Tags | Aerosols, Antineoplastic Agents, Case-Control Studies, clinic, Drug Delivery Systems, Environmental Monitoring, Housekeeping, Hospital, Humans, Medical Staff, Hospital, Occupational Exposure, Occupational hazard, Occupational Health, Occupational safety, Peritoneal Neoplasms, Peritoneum, PIPAC, Pressure, Risk Assessment, Risk Factors |
| Date Added | 2021/09/03 - 08:44:18 |
| Date Modified | 2022/02/04 - 18:14:14 |
| Notes and Attachments | PubMed entry (Attachment) PubMed entry (Attachment) Submitted Version (Attachment) |
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