| Added by | pmartino |
|---|---|
| Group name | EquipePM |
| Item Type | Journal Article |
| Title | Predictive risk factors of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy for ovarian peritoneal carcinomatosis |
| Creator | Angeles et al. |
| Author | Martina Aida Angeles |
| Author | Pierre Vieille |
| Author | Laurence Gladieff |
| Author | Jean Ruiz |
| Author | Muriel Picard |
| Author | Federico Migliorelli |
| Author | Carlos Martínez-Gómez |
| Author | Alejandra Martinez |
| Abstract | OBJECTIVE: The aim of our study was to assess the incidence and identify the predictive risk factors of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy. METHODS: This is a retrospective study from two centers evaluating patients with advanced or recurrent ovarian cancer who underwent cytoreductive surgery followed by cisplatin-based hyperthermic intra-peritoneal chemotherapy from January 2007 to December 2013. Patients were classified into two groups according to the occurrence of acute kidney injury, defined as a glomerular filtration rate at post-operative day 7 25% lower than at day 0. We also evaluated acute kidney injury following Risk, Injury, Failure, Lost and End-stage kidney function criteria. Univariate and multivariate analyses were conducted in order to assess the association between different variables and the occurrence of acute kidney injury. RESULTS: Sixty-six patients were included: 29 (44%) underwent first-line treatment and 37 (56%) were treated for recurrent disease. The incidence of post-operative acute kidney injury was 48%. After multivariate analysis, hypertension (OR 18.6; 95%?CI 1.9 to 182.3; p=0.012) and low intra-operative diuresis (OR 0.5; 95%?CI 0.4 to 0.8; p=0.001) were associated with acute kidney injury. CONCLUSION: The incidence of acute kidney injury after cytoreductive surgery and cisplatin-based hyperthermic intra-peritoneal chemotherapy was high. Hypertension and low intra-operative diuresis were independent risk factors for this complication. Adequate peri-operative hydration, in order to maintain correct diuresis, could decrease the occurrence of acute kidney injury in patients undergoing cytoreductive surgery plus hyperthermic intra-peritoneal chemotherapy. |
| Publication | International Journal of Gynecological Cancer: Official Journal of the International Gynecological Cancer Society |
| Date | Jan 23, 2019 |
| Journal Abbr | Int. J. Gynecol. Cancer |
| Language | eng |
| DOI | 10.1136/ijgc-2018-000099 |
| ISSN | 1525-1438 |
| Library Catalog | PubMed |
| Call Number | IMPACT: 2.192 |
| Extra | IMPACT: 2.192 PMID: 30674567 |
| Tags | clinic, hyperthermic intraperitoneal chemotherapy, peritoneal carcinomatosis, RIFLE and nephrotoxicity |
| Date Added | 2019/02/01 - 18:17:35 |
| Date Modified | 2021/03/05 - 10:43:19 |
| Notes and Attachments | PubMed entry (Attachment) |
Institut de Recherche en Cancérologie de
