| Added by | standudu |
|---|---|
| Last modified by | ircm doc |
| Group name | EquipeAT |
| Item Type | Journal Article |
| Title | Stromal Modulators of TGF-? in Cancer |
| Creator | Costanza et al. |
| Author | Brunella Costanza |
| Author | Ijeoma Adaku Umelo |
| Author | Justine Bellier |
| Author | Vincent Castronovo |
| Author | Andrei Turtoi |
| Abstract | Transforming growth factor-? (TGF-?) is an intriguing cytokine exhibiting dual activities in malignant disease. It is an important mediator of cancer invasion, metastasis and angiogenesis, on the one hand, while it exhibits anti-tumor functions on the other hand. Elucidating the precise role of TGF-? in malignant development and progression requires a better understanding of the molecular mechanisms involved in its tumor suppressor to tumor promoter switch. One important aspect of TGF-? function is its interaction with proteins within the tumor microenvironment. Several stromal proteins have the natural ability to interact and modulate TGF-? function. Understanding the complex interplay between the TGF-? signaling network and these stromal proteins may provide greater insight into the development of novel therapeutic strategies that target the TGF-? axis. The present review highlights our present understanding of how stroma modulates TGF-? activity in human cancers. |
| Publication | Journal of Clinical Medicine |
| Volume | 6 |
| Issue | 1 |
| Date | Jan 06, 2017 |
| Journal Abbr | J Clin Med |
| Language | eng |
| DOI | 10.3390/jcm6010007 |
| ISSN | 2077-0383 |
| Library Catalog | PubMed |
| Extra | PMID: 28067804 PMCID: PMC5294960 |
| Tags | cancer-associated fibroblasts, first-last-corresponding, proteases, proteoglycans, review, stroma, TGF-?, top |
| Date Added | 2019/05/29 - 15:45:27 |
| Date Modified | 2019/05/29 - 15:45:41 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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