| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Radiological response of leptomeningeal metastases according to revised RANO criteria is associated with overall survival in breast cancer patients |
| Creator | Griguolo et al. |
| Author | Gaia Griguolo |
| Author | Vittoria Aldegheri |
| Author | Michele Bottosso |
| Author | Alice Pittaro |
| Author | Francesca Caumo |
| Author | Maria Cristina Guarascio |
| Author | Fabio Busato |
| Author | Federica Miglietta |
| Author | William Jacot |
| Author | Maria Vittoria Dieci |
| Author | Valentina Guarneri |
| Abstract | Assessment of treatment response in patients (pts) with leptomeningeal metastases (LM) represents a significant challenge and standardized criteria are needed. In 2017, the RANO LM Working Group proposed a standardized scorecard to evaluate MRI findings (further simplified in 2019). Here, we aim to validate the prognostic impact of response to treatment assessed using this tool in a multicentric cohort of breast cancer (BC) pts. Pts with BC-related LM diagnosed at two institutions between 2005 and 2018 were identified. Baseline and follow-up MRI scans were centrally reviewed and response assessment was evaluated using 2019 revised RANO LM criteria. A total of 142 pts with BC-related LM and available baseline brain MRI imaging were identified; 60 of them had at least one follow-up MRI. In this subgroup, median overall survival (OS) was 15.2?months (95%CI 9.5-21.0). At first re-evaluation, radiological response by RANO criteria was: complete response (CR) in 2 pts (3%), partial response (PR) in 12 (20%), stable disease (SD) in 33 (55%) and progression of disease (PD) in 13 (22%). Median OS was 31.1?months (HR 0.10, 95%CI 0.01-0.78) in pts with CR, 16.1?months (HR 0.41, 95%CI 0.17-0.97) in pts with PR, 17.9?months (HR 0.45, 95%CI 0.22-0.91) in pts with SD and 9.5?months in pts with PD (P?=?.029). A second blinded evaluation showed a moderate interobserver agreement (K?=?0.562). Radiological response according to 2019 RANO criteria is significantly associated with OS in pts with BC-related LM, thus supporting the use of this evaluation tool both in trials and clinical practice. |
| Publication | International Journal of Cancer |
| Volume | 153 |
| Issue | 6 |
| Pages | 1217-1226 |
| Date | 2023-09-15 |
| Journal Abbr | Int J Cancer |
| Language | eng |
| DOI | 10.1002/ijc.34571 |
| ISSN | 1097-0215 |
| Library Catalog | PubMed |
| Extra | PMID: 37243480 |
| Tags | Breast, breast cancer, Breast Neoplasms, clinic, Female, Humans, leptomeningeal metastases, Magnetic Resonance Imaging, Prognosis, radiological assessment, RANO, Retrospective Studies |
| Date Added | 2023/10/16 - 16:48:50 |
| Date Modified | 2023/10/16 - 17:26:06 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
