| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Differential Sensitivity of Germline and Somatic BRCA Variants to PARP Inhibitor in High-Grade Serous Ovarian Cancer |
| Creator | Vendrell et al. |
| Author | Julie A. Vendrell |
| Author | Iulian O. Ban |
| Author | Isabelle Solassol |
| Author | Patricia Audran |
| Author | Simon Cabello-Aguilar |
| Author | Delphine Topart |
| Author | Clothilde Lindet-Bourgeois |
| Author | Pierre-Emmanuel Colombo |
| Author | Eric Legouffe |
| Author | Véronique D'Hondt |
| Author | Michel Fabbro |
| Author | Jérôme Solassol |
| Abstract | PURPOSE: The introduction of PARP inhibitors (PARPis) as a treatment option for patients with high-grade serous ovarian cancer (HGSOC) modified the approach of BRCA testing worldwide. In this study, we aim to evaluate the impact of BRCA1 and BRCA2 variants on treatment response and survival outcomes in patients diagnosed in our institution. METHODS: A total of 805 HGSOC samples underwent BRCA1 and BRCA2 variant detection by using next-generation sequencing (NGS). Among them, a pathogenic alteration was detected in 104 specimens. Clinicopathological features and germline status were recovered, and alteration types were further characterized. The clinical significance of variant type in terms of response to chemotherapy and to PARPis as well as overall survival were evaluated using univariate analysis. RESULTS: In our cohort, 13.2% of the HGSOC samples harbored a pathogenic BRCA1 or BRCA2 variant, among which 58.7% were inherited. No difference was observed between germline and somatic variants in terms of the gene altered. Interestingly, patients with somatic variants only (no germline) demonstrated better outcomes under PARPi treatment compared to those with germline ones. CONCLUSION: The determination of the inheritance or acquisition of BRCA1 and BRCA2 alterations could provide valuable information for improving management strategies and predicting the outcome of patients with HGSOC. |
| Publication | International Journal of Molecular Sciences |
| Volume | 24 |
| Issue | 18 |
| Pages | 14181 |
| Date | 2023-09-16 |
| Journal Abbr | Int J Mol Sci |
| Language | eng |
| DOI | 10.3390/ijms241814181 |
| ISSN | 1422-0067 |
| Library Catalog | PubMed |
| Extra | PMID: 37762485 PMCID: PMC10532320 |
| Tags | Antineoplastic Agents, BRCA1 and BRCA2 alteration, Clinical Relevance, Female, Germ Cells, germline and somatic variant, Humans, original, Ovarian Neoplasms, PARP inhibitor, Poly(ADP-ribose) Polymerase Inhibitors |
| Date Added | 2023/10/16 - 14:35:52 |
| Date Modified | 2023/10/16 - 17:22:20 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
Institut de Recherche en Cancérologie de
