| Added by | Cavailles |
|---|---|
| Last modified by | informatique.ircm |
| Group name | EquipeVC |
| Item Type | Journal Article |
| Title | RIP140 inhibits glycolysis-dependent proliferation of breast cancer cells by regulating GLUT3 expression through transcriptional crosstalk between hypoxia induced factor and p53 |
| Creator | Jacquier et al. |
| Author | Valentin Jacquier |
| Author | Delphine Gitenay |
| Author | Samuel Fritsch |
| Author | Sandrine Bonnet |
| Author | Balázs Gy?rffy |
| Author | Stéphan Jalaguier |
| Author | Laetitia K. Linares |
| Author | Vincent Cavaillčs |
| Author | Catherine Teyssier |
| Abstract | Glycolysis is essential to support cancer cell proliferation, even in the presence of oxygen. The transcriptional co-regulator RIP140 represses the activity of transcription factors that drive cell proliferation and metabolism and plays a role in mammary tumorigenesis. Here we use cell proliferation and metabolic assays to demonstrate that RIP140-deficiency causes a glycolysis-dependent increase in breast tumor growth. We further demonstrate that RIP140 reduces the transcription of the glucose transporter GLUT3 gene, by inhibiting the transcriptional activity of hypoxia inducible factor HIF-2? in cooperation with p53. Interestingly, RIP140 expression was significantly associated with good prognosis only for breast cancer patients with tumors expressing low GLUT3, low HIF-2? and high p53, thus confirming the mechanism of RIP140 anti-tumor activity provided by our experimental data. Overall, our work establishes RIP140 as a critical modulator of the p53/HIF cross-talk to inhibit breast cancer cell glycolysis and proliferation. |
| Publication | Cellular and molecular life sciences: CMLS |
| Volume | 79 |
| Issue | 5 |
| Pages | 270 |
| Date | 2022-05-03 |
| Journal Abbr | Cell Mol Life Sci |
| Language | eng |
| DOI | 10.1007/s00018-022-04277-3 |
| ISSN | 1420-9071 |
| Library Catalog | PubMed |
| Extra | PMID: 35501580 PMCID: PMC9061696 |
| Tags | Basic Helix-Loop-Helix Transcription Factors, Breast Neoplasms, Cancer cell metabolism, Cell Proliferation, corresponding, Female, first, Glucose Transporter Type 3, GLUT3, HIF, Humans, last, Nuclear Receptor Interacting Protein 1, original, own, p53, premium_IRCM, RIP140, top, Tumor Suppressor Protein p53 |
| Date Added | 2023/11/17 - 17:21:58 |
| Date Modified | 2025/01/10 - 11:02:26 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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