| Added by | adjiane.lab |
|---|---|
| Group name | EquipeAD |
| Item Type | Journal Article |
| Title | Identification of 18F-FDG PET/CT Parameters Associated with Weight Loss in Patients with Esophageal Cancer |
| Creator | Galvez et al. |
| Author | Thierry Galvez |
| Author | Ikrame Berkane |
| Author | Marie-Claude Eberlé |
| Author | Nicolas Flori |
| Author | Sophie Guillemard |
| Author | Alina Diana Ilonca |
| Author | Lore Santoro |
| Author | Pierre-Olivier Kotzki |
| Author | Pierre Senesse |
| Author | Emmanuel Deshayes |
| Abstract | 18F-FDG PET-CT is routinely performed as part of the initial staging of numerous cancers. Other than having descriptive, predictive and prognostic values for tumors, 18F-FDG PET-CT provides full-body data, which could inform on concurrent pathophysiological processes such as malnutrition. To test this hypothesis, we measured the 18F-FDG uptake in several organs and evaluated their association with weight loss in patients at diagnosis of esophageal cancer. Forty-eight patients were included in this retrospective monocentric study. 18F-FDG uptake quantification was performed in the brain, the liver, the spleen, bone marrow, muscle and the esophageal tumor itself and was compared between patients with different amounts of weight loss. We found that Total Lesion Glycolysis (TLG) and peak Standardized Uptake Values (SUVpeak) measured in the brain correlated with the amount of weight loss: TLG was, on average, higher in patients who had lost more than 5% of their usual weight, whereas brain SUVpeak were, on average, lower in patients who had lost more than 10% of their weight. Higher TLG and lower brain SUVpeak were associated with worse OS in the univariate analysis. This study reports a new and significant association between 18F-FDG uptake in the brain and initial weight loss in patients with esophageal cancer. |
| Publication | Nutrients |
| Volume | 15 |
| Issue | 13 |
| Pages | 3042 |
| Date | 2023-07-05 |
| Journal Abbr | Nutrients |
| Language | eng |
| DOI | 10.3390/nu15133042 |
| ISSN | 2072-6643 |
| Library Catalog | PubMed |
| Extra | PMID: 37447367 PMCID: PMC10346913 |
| Tags | 18F-FDG PET/CT, brain metabolism, clinic, Esophageal Neoplasms, first, Fluorodeoxyglucose F18, Humans, Positron Emission Tomography Computed Tomography, Prognosis, Retrospective Studies, Tumor Burden, Weight Loss |
| Date Added | 2023/11/14 - 18:57:06 |
| Date Modified | 2024/09/30 - 18:17:38 |
| Notes and Attachments | Full Text (Attachment) PubMed entry (Attachment) |
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