| Added by | mollevi |
|---|---|
| Last modified by | alainmange |
| Group name | PlateformePP2I |
| Item Type | Journal Article |
| Title | Complementarity of MALDI and LA ICP mass spectrometry for platinum anticancer imaging in human tumor |
| Creator | Bianga et al. |
| Author | Juliusz Bianga |
| Author | Amina Bouslimani |
| Author | Nicole Bec |
| Author | Sandra Mounicou |
| Author | Joanna Szpunar |
| Author | Brice Bouyssiere |
| Author | Ryszard Lobinski |
| Author | Christian Larroque |
| Abstract | The follow-up of the Heated Intraoperative Chemotherapy (HIPEC) of peritoneal carcinomatosis would benefit from the monitoring of the penetration, distribution and metabolism of the drug within the tumor. As tumor nodules can be resected during the therapy, mass spectrometry imaging is a suitable tool for the evaluation of treatment efficacy, and, as a result, the therapy can be re-optimized. In this work we demonstrate the complementarity of laser ablation (LA) ICP mass spectrometry and MALDI imaging to study the penetration and distribution of two Pt-based metallodrugs (cisplatin and oxaliplatin) in human tumor samples removed from patients diagnosed with colorectal or ovarian peritoneal carcinomatosis. LA ICP MS offered sensitive (LOD for (195)Pt 4.8 pg s(-1)) imaging of platinum quasi-independently of the original species and the sample matrix and thus an ultimate way of verifying the penetration of the Pt-containing drug or its moieties into the tumor. MALDI imaging was found to suffer in some cases from signal suppression by the matrix leading to false negatives. In the case of the oxaliplatin metallodrug, the results obtained from ICP and MALDI MS imaging were coherent whereas in the case of cisplatin, species detected by ICP MS imaging could not be validated by MALDI MS. The study is the first application of the dual ICP and MALDI MS imaging to the follow-up of metallodrugs in human tumors. |
| Publication | Metallomics: Integrated Biometal Science |
| Volume | 6 |
| Issue | 8 |
| Pages | 1382-1386 |
| Date | Aug 2014 |
| Journal Abbr | Metallomics |
| Language | eng |
| DOI | 10.1039/c4mt00131a |
| ISSN | 1756-591X |
| Library Catalog | PubMed |
| Extra | PMID: 24984817 |
| Tags | author, Cisplatin, Female, Humans, last, Organoplatinum Compounds, original, Ovarian Neoplasms, Platinum, pp2i, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization |
| Date Added | 2019/06/04 - 17:36:14 |
| Date Modified | 2020/01/14 - 10:26:56 |
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