| Added by | mollevi |
|---|---|
| Group name | EquipeMY |
| Item Type | Journal Article |
| Title | High EGFR protein expression and exon 9 PIK3CA mutations are independent prognostic factors in triple negative breast cancers |
| Creator | Jacot et al. |
| Author | William Jacot |
| Author | Caroline Mollevi |
| Author | Frédéric Fina |
| Author | Evelyne Lopez-Crapez |
| Author | Pierre-Marie Martin |
| Author | Pierre-Emmanuel Colombo |
| Author | Frédéric Bibeau |
| Author | Gilles Romieu |
| Author | Pierre-Jean Lamy |
| Abstract | BACKGROUND: Triple negative breast cancers (TNBC) are a more aggressive subset of breast cancer. A better understanding of its biology could allow the rational development of targeted therapies. METHODS: We extensively analyzed the EGFR/PI3K/PTEN axis in a large, homogeneous population of TNBC to help defining the putative role of anti-EGFR and -PI3K targeted therapies in this setting. EGFR gene amplification, EGFR protein expression, PIK3CA and PTEN gene alterations (two members of EGFR downstream pathways) and their clinicopathological and prognostic implications were analyzed in 204 TNBC samples from European patients. RESULTS: EGFR amplification was detected in 18 of the 204 TNBC specimens (8.9 %) and was significantly associated with higher EGFR protein levels. Fourteen PIK3CA mutations were identified in exon 9 (6.7 %), and 17 in exon 20 (8.3 %). PIK3CA mutations, especially in exon 9, were significantly associated with grade I-II tumors. PTEN deletions were detected in 43 samples (21.50 %) and were significantly associated with grade III tumors (p? |
| Publication | BMC cancer |
| Volume | 15 |
| Pages | 986 |
| Date | Dec 18, 2015 |
| Journal Abbr | BMC Cancer |
| Language | eng |
| DOI | 10.1186/s12885-015-1977-3 |
| ISSN | 1471-2407 |
| Library Catalog | PubMed |
| Extra | PMID: 26680641 PMCID: PMC4683760 |
| Tags | Adult, Aged, Aged, 80 and over, Class I Phosphatidylinositol 3-Kinases, Exons, Female, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Middle Aged, Mutation, original, Phosphatidylinositol 3-Kinases, Prognosis, PTEN Phosphohydrolase, Receptor, Epidermal Growth Factor, Triple Negative Breast Neoplasms |
| Date Added | 2018/11/13 - 17:26:15 |
| Date Modified | 2019/05/21 - 14:50:45 |
Institut de Recherche en Cancérologie de
