| Added by | standudu |
|---|---|
| Group name | EquipeCTCS |
| Item Type | Journal Article |
| Title | Serum Matrix Metalloproteinase-7 is an independent prognostic biomarker in advanced bladder cancer |
| Creator | El Demery et al. |
| Author | M. El Demery |
| Author | G. Demirdjian-Sarkissian |
| Author | S. Thezenas |
| Author | W. Jacot |
| Author | Y. Laghzali |
| Author | B. Darbouret |
| Author | S. Culine |
| Author | X. Rebillard |
| Author | P. J. Lamy |
| Abstract | BACKGROUND: Urine markers have been studied extensively but there is a lack of blood prognostic markers in bladder cancer. MMP-7 is produced by stromal cells and by tumor cells and is overexpressed in a variety of epithelial and mesenchymal tumors. In this study, we assessed with an immunoassay we developed, the prognostic value of serum MMP-7 in a series of patients with advanced bladder cancer. METHODS: Serum samples were collected from 56 patients with advanced bladder cancer who were treated at the Montpellier Cancer Institute between March 2003 and December 2004. MMP-7 was quantified in serum samples by using a homogeneous sandwich fluoroimmunoassay we developed based on the time resolved amplified cryptate emission (TRACE) technology. RESULTS: The median overall survival of the study population was 2.2 years (95% CI, 1.4 to 3.0) with 1- and 5-year survival rates of 73% (95% CI, 59% to 82%) and 25% (95% CI, 14% to 37%), respectively. High MMP-7 serum levels were associated with poor survival. Using a cut-off value of 11.5 ng/mL, the median overall survival was 3.0 years (95% CI, 1.5 to 5.1) for patients with MMP-7 serum level <11.5 ng/mL and 1.3 years (95% CI, 0.8 to 2.5) for patients with serum level ?11.5 ng/mL. Multivariate analysis identified high MMP-7 serum concentration as an independent prognostic factor for survival in patients with advanced bladder cancer (R?=?2.1, 95% CI, 1.1 to 4.4). CONCLUSIONS: Our results show that the MMP-7 serum concentration is an independent prognostic factor in patients with locally advanced and or metastatic bladder cancer. |
| Publication | Clin Transl Med |
| Volume | 3 |
| Pages | 31 |
| Date | 2014 |
| Journal Abbr | Clinical and translational medicine |
| DOI | 10.1186/s40169-014-0031-4 |
| ISSN | 2001-1326 (Electronic) |
| Tags | clinic |
| Date Added | 2018/11/14 - 15:25:02 |
| Date Modified | 2019/05/14 - 19:06:51 |
| Notes and Attachments | (Note) (Note) 25984271 (Attachment) |
Institut de Recherche en Cancérologie de
