| Added by | llecam |
|---|---|
| Group name | EquipeLLC |
| Item Type | Journal Article |
| Title | The multifunctional protein E4F1 links P53 to lipid metabolism in adipocytes |
| Creator | Lacroix et al. |
| Author | Matthieu Lacroix |
| Author | Laetitia K. Linares |
| Author | Natalia Rueda-Rincon |
| Author | Katarzyna Bloch |
| Author | Michela Di Michele |
| Author | Carlo De Blasio |
| Author | Caroline Fau |
| Author | Laurie Gayte |
| Author | Emilie Blanchet |
| Author | Aline Mairal |
| Author | Rita Derua |
| Author | Fernando Cardona |
| Author | Diane Beuzelin |
| Author | Jean-Sebastien Annicotte |
| Author | Nelly Pirot |
| Author | Adeline Torro |
| Author | Francisco J. Tinahones |
| Author | Florence Bernex |
| Author | Justine Bertrand-Michel |
| Author | Dominique Langin |
| Author | Lluis Fajas |
| Author | Johannes V. Swinnen |
| Author | Laurent Le Cam |
| Abstract | Growing evidence supports the importance of the p53 tumor suppressor in metabolism but the mechanisms underlying p53-mediated control of metabolism remain poorly understood. Here, we identify the multifunctional E4F1 protein as a key regulator of p53 metabolic functions in adipocytes. While E4F1 expression is upregulated during obesity, E4f1 inactivation in mouse adipose tissue results in a lean phenotype associated with insulin resistance and protection against induced obesity. Adipocytes lacking E4F1 activate a p53-dependent transcriptional program involved in lipid metabolism. The direct interaction between E4F1 and p53 and their co-recruitment to the Steaoryl-CoA Desaturase-1 locus play an important role to regulate monounsaturated fatty acids synthesis in adipocytes. Consistent with the role of this E4F1-p53-Steaoryl-CoA Desaturase-1 axis in adipocytes, p53 inactivation or diet complementation with oleate partly restore adiposity and improve insulin sensitivity in E4F1-deficient mice. Altogether, our findings identify a crosstalk between E4F1 and p53 in the control of lipid metabolism in adipocytes that is relevant to obesity and insulin resistance. |
| Publication | Nature Communications |
| Volume | 12 |
| Issue | 1 |
| Pages | 7037 |
| Date | 2021-12-02 |
| Journal Abbr | Nat Commun |
| Language | eng |
| DOI | 10.1038/s41467-021-27307-3 |
| ISSN | 2041-1723 |
| Library Catalog | PubMed |
| Extra | PMID: 34857760 PMCID: PMC8639890 |
| Tags | Adipocytes, Adipose Tissue, Adult, Aged, Animals, Body Mass Index, Fatty Acids, Monounsaturated, Female, first, Gene Expression Regulation, Humans, Insulin Resistance, last-corresponding, Male, Mice, Mice, Knockout, Middle Aged, Obesity, original, Repressor Proteins, Signal Transduction, Stearoyl-CoA Desaturase, Tumor Suppressor Protein p53, Ubiquitin-Protein Ligases |
| Date Added | 2022/08/30 - 22:47:09 |
| Date Modified | 2022/08/30 - 22:47:45 |
| Notes and Attachments | PubMed entry (Attachment) Texte intégral (Attachment) |
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